Aromatic Plant-Based Functional Foods: A Natural Approach to Manage Cardiovascular Diseases

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Jul 14

PMID 37446792

Authors

Monica Zuzarte

Henrique Girao

Ligia Salgueiro

Affiliations

Soon will be listed here.

Abstract

Aromatic plants and their essential oils have shown beneficial effects on the cardiovascular system and, therefore, are potential raw materials in the development of functional foods. However, despite their undeniable potential, essential oils present several limitations that need to be addressed, such as stability, poor solubility, undesirable sensory effects, and low bioavailability. The present review provides a current state-of-the-art on the effects of volatile extracts obtained from aromatic plants on the cardiovascular system and focuses on major challenges that need to be addressed to increase their use in food products. Moreover, strategies underway to overcome these limitations are pointed out, thus anticipating a great appreciation of these extracts in the functional food industry.

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References

Alves-Silva J, Zuzarte M, Girao H, Salgueiro L . Natural Products in Cardiovascular Diseases: The Potential of Plants from the Allioideae Subfamily (Ex-Alliaceae Family) and Their Sulphur-Containing Compounds. Plants (Basel). 2022; 11(15). PMC: 9332240. DOI: 10.3390/plants11151920. View

Lahlou S, Figueiredo A, Magalhaes P, Leal-Cardoso J, Gloria P . Cardiovascular effects of methyleugenol, a natural constituent of many plant essential oils, in normotensive rats. Life Sci. 2004; 74(19):2401-12. DOI: 10.1016/j.lfs.2003.09.063. View

Zhao Q, Zhu L, Wang S, Gao Y, Jin F . Molecular mechanism of the anti-inflammatory effects of plant essential oils: A systematic review. J Ethnopharmacol. 2022; 301:115829. DOI: 10.1016/j.jep.2022.115829. View

Veiskaramian A, Gholami M, Yarahmadi S, Baharvand P, Birjandi M . Effect of aromatherapy with Melissa essential oil on stress and hemodynamic parameters in acute coronary syndrome patients: A clinical trial in the emergency department. Complement Ther Clin Pract. 2021; 44:101436. DOI: 10.1016/j.ctcp.2021.101436. View

Ju M, Lee S, Bae I, Hur M, Seong K, Lee M . Effects of aroma massage on home blood pressure, ambulatory blood pressure, and sleep quality in middle-aged women with hypertension. Evid Based Complement Alternat Med. 2013; 2013:403251. PMC: 3570933. DOI: 10.1155/2013/403251. View

Benny A, Thomas J . Essential Oils as Treatment Strategy for Alzheimer's Disease: Current and Future Perspectives. Planta Med. 2018; 85(3):239-248. DOI: 10.1055/a-0758-0188. View

Zhuang X, Deng Z, Mu J, Zhang L, Yan J, Miller D . Ginger-derived nanoparticles protect against alcohol-induced liver damage. J Extracell Vesicles. 2015; 4:28713. PMC: 4662062. DOI: 10.3402/jev.v4.28713. View

Oprea I, Farcas A, Leopold L, Diaconeasa Z, Coman C, Socaci S . Nano-Encapsulation of Citrus Essential Oils: Methods and Applications of Interest for the Food Sector. Polymers (Basel). 2022; 14(21). PMC: 9658967. DOI: 10.3390/polym14214505. View

Shin Y, Hsieh Y, Kwon S, Lee H, Seol G . Linalyl acetate restores endothelial dysfunction and hemodynamic alterations in diabetic rats exposed to chronic immobilization stress. J Appl Physiol (1985). 2018; 124(5):1274-1283. DOI: 10.1152/japplphysiol.01018.2017. View

10.

Alves-Silva J, Zuzarte M, Marques C, Viana S, Preguica I, Baptista R . 1,8-Cineole ameliorates right ventricle dysfunction associated with pulmonary arterial hypertension by restoring connexin43 and mitochondrial homeostasis. Pharmacol Res. 2022; 180:106151. DOI: 10.1016/j.phrs.2022.106151. View

11.

Jackson-Davis A, White S, Kassama L, Coleman S, Shaw A, Mendonca A . A Review of Regulatory Standards and Advances in Essential Oils as Antimicrobials in Foods. J Food Prot. 2023; 86(2):100025. DOI: 10.1016/j.jfp.2022.100025. View

12.

Zuzarte M, Sousa C, Cavaleiro C, Cruz M, Salgueiro L . The Anti-Inflammatory Response of and Essential Oils. Plants (Basel). 2022; 11(3). PMC: 8838270. DOI: 10.3390/plants11030370. View

13.

Alves-Silva J, Zuzarte M, Marques C, Girao H, Salgueiro L . Protective Effects of Phenylpropanoids and Phenylpropanoid-rich Essential Oils on the Cardiovascular System. Mini Rev Med Chem. 2019; 19(17):1459-1471. DOI: 10.2174/1389557519666190620091915. View

14.

Criddle D, Madeira S, de Moura R . Endothelium-dependent and -independent vasodilator effects of eugenol in the rat mesenteric vascular bed. J Pharm Pharmacol. 2003; 55(3):359-65. DOI: 10.1211/002235702694. View

15.

Rahmani A, Niknafs B, Naseri M, Nouri M, Tarighat-Esfanjani A . Effect of Nigella Sativa Oil on Oxidative Stress, Inflammatory, and Glycemic Control Indices in Diabetic Hemodialysis Patients: A Randomized Double-Blind, Controlled Trial. Evid Based Complement Alternat Med. 2022; 2022:2753294. PMC: 9033343. DOI: 10.1155/2022/2753294. View

16.

Awuchi C, Ondari E, Nwozo S, Odongo G, Eseoghene I, Twinomuhwezi H . Mycotoxins' Toxicological Mechanisms Involving Humans, Livestock and Their Associated Health Concerns: A Review. Toxins (Basel). 2022; 14(3). PMC: 8949390. DOI: 10.3390/toxins14030167. View

17.

Tuso P, Stoll S, Li W . A plant-based diet, atherogenesis, and coronary artery disease prevention. Perm J. 2014; 19(1):62-7. PMC: 4315380. DOI: 10.7812/TPP/14-036. View

18.

Zuzarte M, Vitorino C, Salgueiro L, Girao H . Plant Nanovesicles for Essential Oil Delivery. Pharmaceutics. 2022; 14(12). PMC: 9784947. DOI: 10.3390/pharmaceutics14122581. View

19.

Zuzarte M, Francisco V, Neves B, Liberal J, Cavaleiro C, Canhoto J . L´Hér. Essential Oil Inhibits the Inflammatory Response in Macrophages Through Blockade of NF-KB Signaling Cascade. Front Pharmacol. 2022; 12:695911. PMC: 8821966. DOI: 10.3389/fphar.2021.695911. View

20.

Soleimani M, Kashfi L, Mirmohamadkhani M, Ghods A . The effect of aromatherapy with peppermint essential oil on anxiety of cardiac patients in emergency department: A placebo-controlled study. Complement Ther Clin Pract. 2022; 46:101533. DOI: 10.1016/j.ctcp.2022.101533. View