Endothelial Dysfunction in Diabetes Mellitus: New Insights

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 14

PMID 37445881

Authors

Michal Dubsky

Jiri Veleba

Dominika Sojakova

Natalia Marhefkova

Vladimira Fejfarova

Edward B Jude

Affiliations

Soon will be listed here.

Abstract

Endothelial dysfunction (ED) is an important marker of future atherosclerosis and cardiovascular disease, especially in people with diabetes. This article summarizes the evidence on endothelial dysfunction in people with diabetes and adds different perspectives that can affect the presence and severity of ED and its consequences. We highlight that data on ED in type 1 diabetes are lacking and discuss the relationship between ED and arterial stiffness. Several interesting studies have been published showing that ED modulates microRNA, microvesicles, lipid levels, and the endoplasmatic reticulum. A better understanding of ED could provide important insights into the microvascular complications of diabetes, their treatment, and even their prevention.

Citing Articles

S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity.

Zheng H, Yu J, Gao L, Wang K, Xu Z, Zeng Z Nat Commun. 2025; 16(1):1826.

PMID: 39979282 PMC: 11842847. DOI: 10.1038/s41467-025-57124-x.

Tissue nanotransfection-based endothelial PLCγ2-targeted epigenetic gene editing rescues perfusion and diabetic ischemic wound healing.

Verma S, Sen C, Srivastava R, Gnyawali S, Katiyar P, Sahi A Mol Ther. 2025; 33(3):950-969.

PMID: 39863930 PMC: 11897775. DOI: 10.1016/j.ymthe.2025.01.034.

Endothelial Dysfunction and Oxidative Stress in Patients with Severe Coronary Artery Disease: Does Diabetes Play a Contributing Role?.

Boieriu A, Luca C, Neculoiu C, Bisoc A, Tint D Medicina (Kaunas). 2025; 61(1).

PMID: 39859119 PMC: 11767194. DOI: 10.3390/medicina61010135.

Psychological stress level surveys in patients with diabetic foot ulcers and the application effect of using loofah sponges during VSD treatment.

Jin C, Tian Z Am J Transl Res. 2025; 16(12):8032-8042.

PMID: 39822498 PMC: 11733351. DOI: 10.62347/LCRY8746.

Risk Factors and Incidence for In-Stent Restenosis with Drug-Eluting Stent: A Systematic Review and Meta-Analysis.

Liu B, Li M, Liu J, Xie L, Li J, Liu Y Rev Cardiovasc Med. 2025; 25(12):458.

PMID: 39742219 PMC: 11683691. DOI: 10.31083/j.rcm2512458.

References

Anderson T . Arterial stiffness or endothelial dysfunction as a surrogate marker of vascular risk. Can J Cardiol. 2006; 22 Suppl B:72B-80B. PMC: 2780833. DOI: 10.1016/s0828-282x(06)70990-4. View

Love K, Horton W, Patrie J, Jahn L, Hartline L, Barrett E . Predictors of arterial stiffness in adolescents and adults with type 1 diabetes: a cross-sectional study. BMJ Open Diabetes Res Care. 2022; 10(1). PMC: 8734015. DOI: 10.1136/bmjdrc-2021-002491. View

Tamargo J, Agewall S, Borghi C, Ceconi C, Cerbai E, Dan G . New pharmacological agents and novel cardiovascular pharmacotherapy strategies in 2022. Eur Heart J Cardiovasc Pharmacother. 2023; . PMC: 10236523. DOI: 10.1093/ehjcvp/pvad034. View

Creemers E, Tijsen A, Pinto Y . Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?. Circ Res. 2012; 110(3):483-95. DOI: 10.1161/CIRCRESAHA.111.247452. View

Serreli G, Deiana M . Biological Relevance of Extra Virgin Olive Oil Polyphenols Metabolites. Antioxidants (Basel). 2018; 7(12). PMC: 6315336. DOI: 10.3390/antiox7120170. View

Deanfield J, Halcox J, Rabelink T . Endothelial function and dysfunction: testing and clinical relevance. Circulation. 2007; 115(10):1285-95. DOI: 10.1161/CIRCULATIONAHA.106.652859. View

Khorshidi M, Sayyari A, Aryaeian N, Olang B, Alaei M, Khalili M . Effects of omega-3 supplementation on endothelial function, vascular structure, and metabolic parameters in adolescents with type 1 diabetes mellitus: A randomized clinical trial. Front Nutr. 2022; 9:962773. PMC: 9355374. DOI: 10.3389/fnut.2022.962773. View

He Y, Ronsein G, Tang C, Jarvik G, Davidson W, Kothari V . Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles. Circ Res. 2020; 127(9):1198-1210. PMC: 7554159. DOI: 10.1161/CIRCRESAHA.120.317178. View

Takeda Y, Matoba K, Sekiguchi K, Nagai Y, Yokota T, Utsunomiya K . Endothelial Dysfunction in Diabetes. Biomedicines. 2020; 8(7). PMC: 7400447. DOI: 10.3390/biomedicines8070182. View

10.

Vera O, Wulff H, Braun A . Endothelial KCa channels: Novel targets to reduce atherosclerosis-driven vascular dysfunction. Front Pharmacol. 2023; 14:1151244. PMC: 10102451. DOI: 10.3389/fphar.2023.1151244. View

11.

Mironov A, Mironov A, Sanavio B, Krol S, Beznoussenko G . Intracellular Membrane Transport in Vascular Endothelial Cells. Int J Mol Sci. 2023; 24(6). PMC: 10059831. DOI: 10.3390/ijms24065791. View

12.

Martinez-Arroyo O, Ortega A, Flores-Chova A, Sanchez-Garcia B, Garcia-Garcia A, Chaves F . High miR-126-3p levels associated with cardiovascular events in a general population. Eur J Intern Med. 2023; 113:49-56. PMC: 10271715. DOI: 10.1016/j.ejim.2023.04.013. View

13.

Bakhashab S, Yuen Yeoh M, Coulson D, Steel S, Ray S, Weaver J . Deciphering the Role of miR-200c-3p in Type 1 Diabetes (Subclinical Cardiovascular Disease) and Its Correlation with Inflammation and Vascular Health. Int J Mol Sci. 2022; 23(24). PMC: 9778946. DOI: 10.3390/ijms232415659. View

14.

Siddiqui R, Shaikh S, Sech L, Yount H, Stillwell W, Zaloga G . Omega 3-fatty acids: health benefits and cellular mechanisms of action. Mini Rev Med Chem. 2004; 4(8):859-71. DOI: 10.2174/1389557043403431. View

15.

Lau Y, Mustafa M, Choy K, Chan S, Potocnik S, Herbert T . 3',4'-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice. Sci Rep. 2018; 8(1):1818. PMC: 5789000. DOI: 10.1038/s41598-018-19584-8. View

16.

Fluitt M, Mohit N, Gambhir K, Nunlee-Bland G . To the Future: The Role of Exosome-Derived microRNAs as Markers, Mediators, and Therapies for Endothelial Dysfunction in Type 2 Diabetes Mellitus. J Diabetes Res. 2022; 2022:5126968. PMC: 8885279. DOI: 10.1155/2022/5126968. View

17.

Yamasaki Y, Kawamori R, Matsushima H, Nishizawa H, Kodama M, Kubota M . Asymptomatic hyperglycaemia is associated with increased intimal plus medial thickness of the carotid artery. Diabetologia. 1995; 38(5):585-91. DOI: 10.1007/BF00400728. View

18.

Zheng Y, Liu Y, Wang L, Xu H, Lu Z, Xuan Y . MicroRNA‑126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting polo‑like kinase 4. Int J Mol Med. 2021; 47(1):151-160. PMC: 7723505. DOI: 10.3892/ijmm.2020.4775. View

19.

Munir J, Yoon J, Ryu S . Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects. Cells. 2020; 9(10). PMC: 7601381. DOI: 10.3390/cells9102271. View

20.

Bronczek G, Vettorazzi J, Soares G, Kurauti M, Santos C, Bonfim M . The Bile Acid TUDCA Improves Beta-Cell Mass and Reduces Insulin Degradation in Mice With Early-Stage of Type-1 Diabetes. Front Physiol. 2019; 10:561. PMC: 6529580. DOI: 10.3389/fphys.2019.00561. View