Research Advances on the Bioactivity of 1,2,3-Triazolium Salts

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 14

PMID 37445872

Authors

Jia Song

Jie Lv

Jiamiao Jin

Zhichao Jin

Tingting Li

Jian Wu

Affiliations

Soon will be listed here.

Abstract

1,2,3-Triazolium salts have demonstrated significant potential in the fields of medicine and agriculture, exhibiting exceptional antibacterial, antifungal, anticancer, and antileishmanial properties. Moreover, these salts can be utilized as additives or components to produce nano- and fiber-based materials with antibacterial properties. In this review, we summarize several synthetic strategies to obtain 1,2,3-triazolium salts and the structures of 1,2,3-triazolium derivatives with biological activities in the domains of pharmaceuticals, pesticides, and functional materials. Additionally, the structure-activity relationship (SAR) of 1,2,3-triazolium salts with different biological activities has been analyzed. Finally, this review presents the potential applications and prospects of 1,2,3-triazolium salts in the fields of agriculture, medicine, and industrial synthesis.

Citing Articles

Aniline Derivatives Containing 1-Substituted 1,2,3-Triazole System as Potential Drug Candidates: Pharmacokinetic Profile Prediction, Lipophilicity Analysis Using Experimental and In Silico Studies.

Chrobak E, Bober-Majnusz K, Wyszomirski M, Zieba A Pharmaceuticals (Basel). 2024; 17(11).

PMID: 39598388 PMC: 11597839. DOI: 10.3390/ph17111476.

Efficient Access to New Thienobenzo-1,2,3-Triazolium Salts as Preferred Dual Cholinesterase Inhibitors.

Mlakic M, Sviben M, Ratkovic A, Raspudic A, Baric D, Sagud I Biomolecules. 2024; 14(11).

PMID: 39595567 PMC: 11591901. DOI: 10.3390/biom14111391.

New Charged Cholinesterase Inhibitors: Design, Synthesis, and Characterization.

Mlakic M, Baric D, Ratkovic A, Sagud I, cipor I, Piantanida I Molecules. 2024; 29(7).

PMID: 38611900 PMC: 11013433. DOI: 10.3390/molecules29071622.

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