Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and After Maintenance Therapy: A Case Study

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 14

PMID 37445821

Authors

Rodrigo Pessoa

Daniela Raguer Valadao de Souza

Youko Nukui

Juliana Pereira

Lorena Abreu Fernandes

Rosa Nascimento Marcusso

Augusto Cesar Penalva de Oliveira

Jorge Casseb

Alberto Jose da Silva Duarte

Sabri Saeed Sanabani

Affiliations

Soon will be listed here.

Abstract

Small RNAs (sRNAs) are epigenetic regulators of essential biological processes associated with the development and progression of leukemias, including adult T-cell leukemia/lymphoma (ATLL) caused by human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic human retrovirus originally discovered in a patient with adult T-cell leukemia/lymphoma. Here, we describe the sRNA profile of a 30-year-old woman with ATLL at the time of diagnosis and after maintenance therapy with the aim of correlating expression levels with response to therapy.

References

Chang T, Zeitels L, Hwang H, Chivukula R, Wentzel E, Dews M . Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A. 2009; 106(9):3384-9. PMC: 2651245. DOI: 10.1073/pnas.0808300106. View

Nahand J, Karimzadeh M, Nezamnia M, Fatemipour M, Khatami A, Jamshidi S . The role of miR-146a in viral infection. IUBMB Life. 2020; 72(3):343-360. DOI: 10.1002/iub.2222. View

Gessain A, Cassar O . Epidemiological Aspects and World Distribution of HTLV-1 Infection. Front Microbiol. 2012; 3:388. PMC: 3498738. DOI: 10.3389/fmicb.2012.00388. View

Nasr R, Rosenwald A, El-Sabban M, Arnulf B, Zalloua P, Lepelletier Y . Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells. Blood. 2003; 101(11):4576-82. DOI: 10.1182/blood-2002-09-2986. View

Ungefroren H, Groth S, Sebens S, Lehnert H, Gieseler F, Fandrich F . Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. Mol Cancer. 2011; 10:67. PMC: 3112431. DOI: 10.1186/1476-4598-10-67. View

Bazarbachi A, El-Sabban M, Nasr R, Quignon F, Awaraji C, Kersual J . Arsenic trioxide and interferon-alpha synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells. Blood. 1998; 93(1):278-83. View

Bender T, Kremer C, Kraus M, Buch T, Rajewsky K . Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol. 2004; 5(7):721-9. DOI: 10.1038/ni1085. View

Luo K, Lodish H . Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues. EMBO J. 1997; 16(8):1970-81. PMC: 1169800. DOI: 10.1093/emboj/16.8.1970. View

Shimoyama M . Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). Br J Haematol. 1991; 79(3):428-37. DOI: 10.1111/j.1365-2141.1991.tb08051.x. View

10.

Yuan C, Zhang Y, Tu W, Guo Y . Integrated miRNA profiling and bioinformatics analyses reveal upregulated miRNAs in gastric cancer. Oncol Lett. 2019; 18(2):1979-1988. PMC: 6607103. DOI: 10.3892/ol.2019.10495. View

11.

Agirre X, Jimenez-Velasco A, Jose-Eneriz E, Garate L, Bandres E, Cordeu L . Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth. Mol Cancer Res. 2008; 6(12):1830-40. DOI: 10.1158/1541-7786.MCR-08-0167. View

12.

Wang X, Angelis N, Thein S . MYB - A regulatory factor in hematopoiesis. Gene. 2018; 665:6-17. PMC: 10764194. DOI: 10.1016/j.gene.2018.04.065. View

13.

Lin X, Liu X, Zhang Y, Li N, Yang Z, Fu W . Integrated analysis of microRNA and transcription factor reveals important regulators and regulatory motifs in adult B-cell acute lymphoblastic leukemia. Int J Oncol. 2017; 50(2):671-683. DOI: 10.3892/ijo.2016.3832. View

14.

Gottmann P, Ouni M, Saussenthaler S, Roos J, Stirm L, Jahnert M . A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes. Mol Metab. 2018; 11:145-159. PMC: 6001404. DOI: 10.1016/j.molmet.2018.03.005. View

15.

Dong N, Xu B, Benya S, Tang X . MiRNA-26b inhibits the proliferation, migration, and epithelial-mesenchymal transition of lens epithelial cells. Mol Cell Biochem. 2014; 396(1-2):229-38. DOI: 10.1007/s11010-014-2158-4. View

16.

Sampath D, Calin G, Puduvalli V, Gopisetty G, Taccioli C, Liu C . Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation. Blood. 2008; 113(16):3744-53. PMC: 2670791. DOI: 10.1182/blood-2008-09-178707. View

17.

Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y . The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim. Gastroenterology. 2009; 136(5):1689-700. PMC: 2887605. DOI: 10.1053/j.gastro.2009.02.002. View

18.

Ariumi Y, Kaida A, Lin J, Hirota M, Masui O, Yamaoka S . HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration. Oncogene. 2000; 19(12):1491-9. DOI: 10.1038/sj.onc.1203450. View

19.

de Souza D, Pessoa R, Nascimento A, Nukui Y, Pereira J, Casseb J . Small RNA profiles of HTLV-1 asymptomatic carriers with monoclonal and polyclonal rearrangement of the T-cell antigen receptor γ-chain using massively parallel sequencing: A pilot study. Oncol Lett. 2020; 20(3):2311-2321. PMC: 7400997. DOI: 10.3892/ol.2020.11803. View

20.

Vasilatou D, Papageorgiou S, Pappa V, Papageorgiou E, Dervenoulas J . The role of microRNAs in normal and malignant hematopoiesis. Eur J Haematol. 2009; 84(1):1-16. DOI: 10.1111/j.1600-0609.2009.01348.x. View