Cross-Kingdom Interaction of MiRNAs and Gut Microbiota with Non-Invasive Diagnostic and Therapeutic Implications in Colorectal Cancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jul 14

PMID 37445698

Authors

Ondrej Pos

Jakub Styk

Gergely Buglyo

Michal Zeman

Lydia Lukyova

Kamila Bernatova

Evelina Hrckova Turnova

Tomas Rendek

Adam Csok

Vanda Repiska

Balint Nagy

Tomas Szemes

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) has one of the highest incidences among all types of malignant diseases, affecting millions of people worldwide. It shows slow progression, making it preventable. However, this is not the case due to shortcomings in its diagnostic and management procedure and a lack of effective non-invasive biomarkers for screening. Here, we discuss CRC-associated microRNAs (miRNAs) and gut microbial species with potential as CRC diagnostic and therapy biomarkers. We provide rich evidence of cross-kingdom miRNA-mediated interactions between the host and gut microbiome. miRNAs have emerged with the ability to shape the composition and dynamics of gut microbiota. Intestinal microbes can uptake miRNAs, which in turn influence microbial growth and provide the ability to regulate the abundance of various microbial species. In the context of CRC, targeting miRNAs could aid in manipulating the balance of the microbiota. Our findings suggest the need for correlation analysis between the composition of the gut microbiome and the miRNA expression profile.

Citing Articles

Serum Cytokine and miRNA Levels Are Differently Expressed in Right- and Left-Sided Colon Cancer.

De Nunzio V, Donghia R, Pesole P, Coletta S, Calo N, Notarnicola M J Clin Med. 2023; 12(18).

PMID: 37762927 PMC: 10532301. DOI: 10.3390/jcm12185986.

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