Super Formula for Diagnosing Disseminated Intravascular Coagulation Using Soluble C-Type Lectin-like Receptor 2

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2023 Jul 14

PMID 37443690

Authors

Akitaka Yamamoto

Hideo Wada

Masaki Tomida

Yuhuko Ichikawa

Minoru Ezaki

Katsuya Shiraki

Motomu Shimaoka

Toshiaki Iba

Katsue Suzuki-Inoue

Masahide Kawamura

Hideto Shimpo

Affiliations

Soon will be listed here.

Abstract

Materials And Methods: The diagnostic usefulness of sCLEC-2 and several formulas, including sCLEC-2xD-dimer, sCLEC-2/platelet count (sCLEC-2/PLT), and sCLEC-2/PLT × D-dimer (sCLEC-2xD-dimer/PLT), were evaluated among 38 patients with DIC, 39 patients with pre-DIC and 222 patients without DIC or pre-DIC (non-DIC).

Results: Although the plasma level of sCLEC-2 alone was not a strong biomarker for the diagnosis of DIC or pre-DIC, the sCLEC-2xD-dimer/PLT values in patients with DIC were significantly higher than those in patients without DIC, and in a receiver operating characteristic (ROC) analysis for the diagnosis of DIC, sCLEC-2xD-dimer/PLT showed the highest AUC, sensitivity, and odds ratio. This formula is useful for the diagnosis of both pre-DIC and DIC. sCLEC-2xD-dimer/PLT values were significantly higher in non-survivors than in survivors.

Conclusion: The sCLEC-2xD-dimer/PLT formula is simple, easy, and highly useful for the diagnosis of DIC and pre-DIC without the use of a scoring system.

Citing Articles

Detection of Thrombosis Using Soluble C-Type Lectin-like Receptor-2 with D-Dimer Level and Platelet Count.

Wada H, Shiraki K, Yamamoto A, Kamon T, Masuda J, Ichikawa Y J Clin Med. 2024; 13(19).

PMID: 39408040 PMC: 11477887. DOI: 10.3390/jcm13195980.

Super Formula for Soluble C-Type Lectin-Like Receptor 2 × D-Dimer in Patients With Acute Cerebral Infarction.

Kamon T, Wada H, Horie S, Inaba T, Okamoto K, Shiraki K Clin Appl Thromb Hemost. 2024; 30:10760296241232858.

PMID: 38403943 PMC: 10896059. DOI: 10.1177/10760296241232858.

Reply to Ishikura, H. What Does Soluble C-Type Lectin-like Receptor 2 (sCLEC-2) × D-Dimer/Platelet (PLT) (sCLEC-2 × D-Dimer/PLT) Mean for Coagulation/Fibrinolysis Conditions? Comment on "Yamamoto et al. Super Formula for Diagnosing Disseminated....

Wada H, Yamamoto A, Shiraki K, Shimpo H Diagnostics (Basel). 2024; 14(1).

PMID: 38201352 PMC: 10795762. DOI: 10.3390/diagnostics14010042.

What Does Soluble C-Type Lectin-like Receptor 2 (sCLEC-2) × D-Dimer/Platelet (PLT) (sCLEC-2 × D-Dimer/PLT) Mean for Coagulation/Fibrinolysis Conditions? Comment on Yamamoto et al. Super Formula for Diagnosing Disseminated Intravascular Coagulation....

Ishikura H Diagnostics (Basel). 2024; 14(1).

PMID: 38201351 PMC: 10802215. DOI: 10.3390/diagnostics14010041.

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