Tanshinone IIA Targeting Cell Signaling Pathways: a Plausible Paradigm for Cancer Therapy

Overview

Journal Pharmacol Rep

Specialty Pharmacology

Date 2023 Jul 13

PMID 37440106

Authors

Syed Sahajada Mahafujul Alam

Arijit Samanta

Faizan Uddin

Safdar Ali

Mehboob Hoque

Affiliations

Soon will be listed here.

Abstract

Natural compounds originating from plants offer a wide range of pharmacological potential and have traditionally been used to treat a wide range of diseases including cancer. Tanshinone IIA (Tan IIA), a bioactive molecule found in the roots of the Traditional Chinese Medicine (TCM) herb Salvia miltiorrhiza, has been shown to have remarkable anticancer properties through several mechanisms, such as inhibition of tumor cell growth and proliferation, metastasis, invasion, and angiogenesis, as well as induction of apoptosis and autophagy. It has demonstrated excellent anticancer efficacy against cell lines from breast, cervical, colorectal, gastric, lung, and prostate cancer by modulating multiple signaling pathways including PI3K/Akt, JAK/STAT, IGF-1R, and Bcl-2-Caspase pathways. This review focuses on the role of Tan IIA in the treatment of various cancers, as well as the underlying molecular mechanisms.

Citing Articles

Probing the role of Coniferin and Tetrahydrocurcumin from Traditional Chinese medicine against PSAT1 in early-stage ovarian cancer: An in silico study.

Zhang J, Gangwar S, Bano N, Ahmad S, AlQahtani M, Raza K PLoS One. 2025; 20(2):e0313585.

PMID: 39913473 PMC: 11801603. DOI: 10.1371/journal.pone.0313585.

An Update on Recent Studies Focusing on the Antioxidant Properties of Species.

Iacopetta D, Ceramella J, Scumaci D, Catalano A, Sinicropi M, Tundis R Antioxidants (Basel). 2023; 12(12).

PMID: 38136225 PMC: 10740915. DOI: 10.3390/antiox12122106.

Miltiradiene Production by Cytoplasmic Metabolic Engineering in .

Ren X, Lin C, Huang Y, Su T, Guo J, Yang L Metabolites. 2023; 13(12).

PMID: 38132870 PMC: 10745046. DOI: 10.3390/metabo13121188.

References

Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A . Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3):209-249. DOI: 10.3322/caac.21660. View

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

Gotwals P, Cameron S, Cipolletta D, Cremasco V, Crystal A, Hewes B . Prospects for combining targeted and conventional cancer therapy with immunotherapy. Nat Rev Cancer. 2017; 17(5):286-301. DOI: 10.1038/nrc.2017.17. View

Topalian S, Drake C, Pardoll D . Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell. 2015; 27(4):450-61. PMC: 4400238. DOI: 10.1016/j.ccell.2015.03.001. View

Huang C, Ju D, Chang C, Reddy P, Velmurugan B . A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomedicine (Taipei). 2017; 7(4):23. PMC: 5682982. DOI: 10.1051/bmdcn/2017070423. View

Hashem S, Ali T, Akhtar S, Nisar S, Sageena G, Ali S . Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents. Biomed Pharmacother. 2022; 150:113054. DOI: 10.1016/j.biopha.2022.113054. View

Wang H, Khor T, Shu L, Su Z, Fuentes F, Lee J . Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem. 2012; 12(10):1281-305. PMC: 4017674. DOI: 10.2174/187152012803833026. View

Jiang Z, Gao W, Huang L . Tanshinones, Critical Pharmacological Components in . Front Pharmacol. 2019; 10:202. PMC: 6426754. DOI: 10.3389/fphar.2019.00202. View

Ansari M, Khan F, Safdari H, Almatroudi A, Alzohairy M, Safdari M . Prospective therapeutic potential of Tanshinone IIA: An updated overview. Pharmacol Res. 2020; 164:105364. DOI: 10.1016/j.phrs.2020.105364. View

10.

Fu L, Han B, Zhou Y, Ren J, Cao W, Patel G . The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients. Front Pharmacol. 2020; 11:193. PMC: 7098175. DOI: 10.3389/fphar.2020.00193. View

11.

Lv C, Zeng H, Wang J, Yuan X, Zhang C, Fang T . The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG. Cell Death Dis. 2018; 9(2):165. PMC: 5833361. DOI: 10.1038/s41419-017-0247-5. View

12.

Won S, Lee H, Jeong S, Lee H, Lee E, Jung D . Tanshinone IIA induces mitochondria dependent apoptosis in prostate cancer cells in association with an inhibition of phosphoinositide 3-kinase/AKT pathway. Biol Pharm Bull. 2010; 33(11):1828-34. DOI: 10.1248/bpb.33.1828. View

13.

Zhong C, Lin Z, Ke L, Shi P, Li S, Huang L . Recent Research Progress (2015-2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA. Front Pharmacol. 2021; 12:778847. PMC: 8606659. DOI: 10.3389/fphar.2021.778847. View

14.

Dong Y, Morris-Natschke S, Lee K . Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents. Nat Prod Rep. 2011; 28(3):529-42. DOI: 10.1039/c0np00035c. View

15.

Gao W, Sun H, Xiao H, Cui G, Hillwig M, Jackson A . Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza. BMC Genomics. 2014; 15:73. PMC: 3913955. DOI: 10.1186/1471-2164-15-73. View

16.

Guo J, Zhou Y, Hillwig M, Shen Y, Yang L, Wang Y . CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. Proc Natl Acad Sci U S A. 2013; 110(29):12108-13. PMC: 3718111. DOI: 10.1073/pnas.1218061110. View

17.

Rohmer M, Knani M, SIMONIN P, Sutter B, Sahm H . Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. Biochem J. 1993; 295 ( Pt 2):517-24. PMC: 1134910. DOI: 10.1042/bj2950517. View

18.

Rodriguez-Concepcion M, Boronat A . Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. Plant Physiol. 2002; 130(3):1079-89. PMC: 1540259. DOI: 10.1104/pp.007138. View

19.

Kai G, Xu H, Zhou C, Liao P, Xiao J, Luo X . Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures. Metab Eng. 2011; 13(3):319-27. DOI: 10.1016/j.ymben.2011.02.003. View

20.

Ma Y, Yuan L, Wu B, Li X, Chen S, Lu S . Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. J Exp Bot. 2012; 63(7):2809-23. PMC: 3346237. DOI: 10.1093/jxb/err466. View