The Emerging Role of MicroRNA-182 in Tumorigenesis; a Promising Therapeutic Target

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2023 Jul 12

PMID 37438760

Authors

Pouriya Sameti

Maryam Tohidast

Mohammad Amini

Seyedeh Zahra Bahojb Mahdavi

Souzan Najafi

Ahad Mokhtarzadeh

Affiliations

Soon will be listed here.

Abstract

A wide range of studies have indicated that microRNAs (miRNAs), a type of small single-stranded regulatory RNAs, are dysregulated in a different variety of human cancers. Therefore, they are expected to play important roles in tumorigenesis by functioning as oncogenic (oncomiRs) or tumor-suppressive miRNAs. Subsequently, their potential as diagnostic and therapeutic targets for malignancies has attracted attention in recent years. In particular, studies have revealed the aberrant expression of miR-182 through tumorigenesis and its important roles in various aspects of malignancies, including proliferation, metastasis, and chemoresistance. Accumulating reports have illustrated that miR-182, as a dual-role regulator, directly or indirectly regulates the expression of a wide range of genes and modulates the activity of various signaling pathways involved in tumor progression, such as JAK / STAT3, Wnt / β-catenin, TGF-β, and P13K / AKT. Therefore, considering the high therapeutic and diagnostic potential of miR-182, this review aims to point out the effects of miR-182 dysregulation on the signaling pathways involved in tumorigenesis.

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