Which Method is More Effective in Predicting Adult Height in Pubertal Girls Treated with Gonadotropin-releasing Hormone Agonist?

Overview

Journal Hormones (Athens)

Specialty Endocrinology

Date 2023 Jul 12

PMID 37436638

Authors

Gozde Akin Kagizmanli

Reyhan Deveci Sevim

Ozge Besci

Kubra Yuksek Acinikli

Aysen Hazal Buran

Ibrahim Mert Erbas

Ece Bober

Korcan Demir

Ahmet Anik

Ayhan Abaci

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of the present study was to determine the efficiency of three different predictive models [Bayley-Pinneau (BP), Roche-Wainer-Thissen (RWT), and Tanner-Whitehouse 2 (TW2)] by comparing their predictions with near-adult height data of girls receiving gonadotropin-releasing hormone agonist (GnRHa) therapy.

Methods: Clinical findings were retrospectively analyzed. Bone ages obtained before treatment were evaluated from left hand and wrist radiographs by three researchers. Predicted adult height (PAH) was calculated using the BP, RWT, and TW2 methods for each patient at the beginning of therapy.

Results: The median age at diagnosis of the 48 patients included in the study was 8.8 (8.9-9.3) years. There was no significant difference between the mean bone ages evaluated separately with the Greulich-Pyle atlas and the TW3-RUS method (p=0.34). Among the PAH methods, only PAH measured by the BP method was very close to and no different from near adult height (NAH) [159.8±6.3 vs. 158.8±9.3 cm. p=0.3; (-0.5±1.1) vs. (-0.7±1.6) standard deviation score, p=0.1]. Accordingly, the BP method was found to be the most accurate prediction tool in girls with puberty treated with GnRHa.

Conclusion: The BP method is more effective at predicting adult height than the RWT and TW2 methods in female patients who will receive GnRHa treatment.

References

Sultan C, Gaspari L, Maimoun L, Kalfa N, Paris F . Disorders of puberty. Best Pract Res Clin Obstet Gynaecol. 2018; 48:62-89. DOI: 10.1016/j.bpobgyn.2017.11.004. View

Klein D, Emerick J, Sylvester J, Vogt K . Disorders of Puberty: An Approach to Diagnosis and Management. Am Fam Physician. 2017; 96(9):590-599. View

Bereket A . A Critical Appraisal of the Effect of Gonadotropin-Releasing Hormon Analog Treatment on Adult Height of Girls with Central Precocious Puberty. J Clin Res Pediatr Endocrinol. 2017; 9(Suppl 2):33-48. PMC: 5790330. DOI: 10.4274/jcrpe.2017.S004. View

Cheuiche A, da Silveira L, de Paula L, Lucena I, Silveiro S . Diagnosis and management of precocious sexual maturation: an updated review. Eur J Pediatr. 2021; 180(10):3073-3087. DOI: 10.1007/s00431-021-04022-1. View

Bangalore Krishna K, Fuqua J, Rogol A, Klein K, Popovic J, Houk C . Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International Consortium. Horm Res Paediatr. 2019; 91(6):357-372. DOI: 10.1159/000501336. View

Labarta J, Ranke M, Maghnie M, Martin D, Guazzarotti L, Pfaffle R . Important Tools for Use by Pediatric Endocrinologists in the Assessment of Short Stature. J Clin Res Pediatr Endocrinol. 2020; 13(2):124-135. PMC: 8186334. DOI: 10.4274/jcrpe.galenos.2020.2020.0206. View

Erbas I, Olmez Z, Paketci A, Demir K, Bober E, Abaci A . Comparison of the Effectiveness of Adult Height Prediction Methods in Children with Growth Hormone Deficiency. Endocr Res. 2021; 46(3):140-147. DOI: 10.1080/07435800.2021.1916029. View

Jeong S, Cho J, Jung H, Shim K . Near final height in Korean children referred for evaluation of short stature: clinical utility and analytical validity of height prediction methods. Ann Pediatr Endocrinol Metab. 2018; 23(1):28-32. PMC: 5894566. DOI: 10.6065/apem.2018.23.1.28. View

Bueno Lozano G, Ruibal Francisco J, Reverte Blanc F, CASADO de FRIAS E . [Accuracy of the methods for height prediction in patients treated for congenital primary hypothyroidism]. An Esp Pediatr. 1998; 47(6):595-600. View

10.

Bramswig J, Fasse M, Holthoff M, Von Lengerke H, Von Petrykowski W, Schellong G . Adult height in boys and girls with untreated short stature and constitutional delay of growth and puberty: accuracy of five different methods of height prediction. J Pediatr. 1990; 117(6):886-91. DOI: 10.1016/s0022-3476(05)80127-1. View

11.

Roemmich J, Blizzard R, Peddada S, Malina R, Roche A, Tanner J . Longitudinal assessment of hormonal and physical alterations during normal puberty in boys. IV: Predictions of adult height by the Bayley-Pinneau, Roche-Wainer-Thissen, and Tanner-Whitehouse methods compared. Am J Hum Biol. 2017; 9(3):371-380. DOI: 10.1002/(SICI)1520-6300(1997)9:3<371::AID-AJHB9>3.0.CO;2-0. View

12.

Resende E, Lara B, Reis J, Ferreira B, Pereira G, Borges M . Assessment of basal and gonadotropin-releasing hormone-stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children. J Clin Endocrinol Metab. 2007; 92(4):1424-9. DOI: 10.1210/jc.2006-1569. View

13.

Demir K, Konakci E, Ozkaya G, Demir B, Ozen S, Aydin M . New Features for Child Metrics: Further Growth References and Blood Pressure Calculations. J Clin Res Pediatr Endocrinol. 2019; 12(2):125-129. PMC: 7291402. DOI: 10.4274/jcrpe.galenos.2019.2019.0127. View

14.

Neyzi O, Bundak R, Gokcay G, Gunoz H, Furman A, Darendeliler F . Reference Values for Weight, Height, Head Circumference, and Body Mass Index in Turkish Children. J Clin Res Pediatr Endocrinol. 2016; 7(4):280-93. PMC: 4805217. DOI: 10.4274/jcrpe.2183. View

15.

Tanner J . Normal growth and techniques of growth assessment. Clin Endocrinol Metab. 1986; 15(3):411-51. DOI: 10.1016/s0300-595x(86)80005-6. View

16.

Bayley N, PINNEAU S . Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr. 1952; 40(4):423-41. DOI: 10.1016/s0022-3476(52)80205-7. View

17.

Roche A, Wainer H, Thissen D . The RWT method for the prediction of adult stature. Pediatrics. 1975; 56(6):1027-33. View

18.

ZACHMANN M, Sobradillo B, Frank M, Frisch H, PRADER A . Bayley-Pinneau, Roche-Wainer-Thissen, and Tanner height predictions in normal children and in patients with various pathologic conditions. J Pediatr. 1978; 93(5):749-55. DOI: 10.1016/s0022-3476(78)81071-3. View

19.

JOSS E, Schmidt H, ZUPPINGER K . Oxandrolone in constitutionally delayed growth, a longitudinal study up to final height. J Clin Endocrinol Metab. 1989; 69(6):1109-15. DOI: 10.1210/jcem-69-6-1109. View

20.

Maes M, Vandeweghe M, Du Caju M, Ernould C, Bourguignon J, Massa G . A valuable improvement of adult height prediction methods in short normal children. Horm Res. 1997; 48(4):184-90. DOI: 10.1159/000185511. View