Runt-related Transcription Factors and Gene Regulatory Mechanisms in Skeletal Development and Diseases

Overview

Journal Curr Osteoporos Rep

Publisher Current Science

Specialties Endocrinology
Orthopedics

Date 2023 Jul 12

PMID 37436583

Authors

Hironori Hojo

Shinsuke Ohba

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Runt-related transcription factors (RUNX) play critical roles in skeletal development, metabolism, and diseases. In mammals, three RUNX members, namely RUNX1, RUNX2, and RUNX3, play distinct and redundant roles, although RUNX2 is a dominant factor in skeletal development and several skeletal diseases. This review is to provide an overview of the current understanding of RUNX-mediated transcriptional regulation in different skeletal cell types.

Recent Findings: Advances in chromatin immunoprecipitation and next-generation sequencing (ChIP-seq) have revealed genome-wide RUNX-mediated gene regulatory mechanisms, including their association with cis-regulatory elements and putative target genes. Further studies with genome-wide analysis and biochemical assays have shed light on RUNX-mediated pioneering action and involvements of RUNX2 in lipid-lipid phase separation. Emerging multi-layered mechanisms of RUNX-mediated gene regulations help us better understanding of skeletal development and diseases, which also provides clues to think how genome-wide studies can help develop therapeutic strategies for skeletal diseases.

Citing Articles

Nanoquantification of RUNX2 by a 1,1'-carbonyldiimidazole-diamond mediated sandwich assay for osteogenic differentiation.

Sun Q, Zhu W, Shi E, Bai M, Liu Z, Yang Z Heliyon. 2024; 10(11):e31837.

PMID: 38868000 PMC: 11167296. DOI: 10.1016/j.heliyon.2024.e31837.

[Latest Findings on the Role of RUNX1 in Bone Development and Disorders].

Pan Z, Zhou X, Cao Z, Pan J Sichuan Da Xue Xue Bao Yi Xue Ban. 2024; 55(2):256-262.

PMID: 38645858 PMC: 11026898. DOI: 10.12182/20240360103.

[Research on Runx2 gene induced differentiation of human amniotic mesenchymal stem cells into ligament fibroblasts and promotion of tendon-bone healing in rabbits].

Xie T, Zhong H, Jin Y, Liu X, Chen F, Xiang K Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023; 37(12):1523-1532.

PMID: 38130197 PMC: 10739672. DOI: 10.7507/1002-1892.202306010.

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