» Articles » PMID: 37435548

Lung Cancer Resembling Allergic Bronchopulmonary Mycosis with an Asthma-like Presentation

Overview
Date 2023 Jul 12
PMID 37435548
Authors
Affiliations
Soon will be listed here.
Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is a lung disorder caused by a hypersensitivity reaction to antigens of the . Recently, allergic bronchopulmonary mycosis (ABPM) caused by fungi other than but with the same symptoms has been described. ABPM commonly affects patients with allergic diseases including bronchial asthma. ABPM is characterized by radiographic appearance, with the most common findings being proximal bronchiectasis and signs of mucoid impaction. However, the differentiation of ABPM is often necessary to enable accurate diagnosis of lung cancer. A 73-year-old man visited the outpatient clinic with symptoms of exertional dyspnea. He was diagnosed with ABPM due to suspicious bronchiectasis and mucoid impaction observed in computed tomography (CT) of his chest. After 3 months, he visited our hospital with continued exertional dyspnea and suspicion of a possible tumor in his lung. Marked eosinophilia and high-attenuation mucus impaction were not taken into consideration as diagnosis was conducted as per clinical diagnostic criteria for ABPA/ABPM. We hereby report a case of lung cancer in a patient initially evaluated for suspected ABPM of the right lung. The diagnosis of lung cancer was established using bronchoscopy. If any definitive diagnosis is not achieved by following the clinical diagnostic criteria for ABPM, physicians should achieve a histological diagnosis by performing a prompt bronchoscopy.

Citing Articles

Clinical Relevance of Elevated Serum Carcinoembryonic Antigen in Allergic Bronchopulmonary Aspergillosis/Mycosis: A Multicenter Retrospective Study.

Ge H, Cai R, Chen X, Liu B, Hu X, Deng S J Asthma Allergy. 2024; 17:1313-1323.

PMID: 39737334 PMC: 11683200. DOI: 10.2147/JAA.S494250.

References
1.
Agarwal R, Muthu V, Sehgal I, Dhooria S, Prasad K, Aggarwal A . Allergic Bronchopulmonary Aspergillosis. Clin Chest Med. 2022; 43(1):99-125. DOI: 10.1016/j.ccm.2021.12.002. View

2.
Phuyal S, Garg M, Agarwal R, Gupta P, Chakrabarti A, Sandhu M . High-Attenuation Mucus Impaction in Patients With Allergic Bronchopulmonary Aspergillosis: Objective Criteria on High-Resolution Computed Tomography and Correlation With Serologic Parameters. Curr Probl Diagn Radiol. 2015; 45(3):168-73. DOI: 10.1067/j.cpradiol.2015.07.006. View

3.
Tamura A, Hebisawa A, Kurashima A, Kawabe Y, Machida K, Yotsumoto H . The use of bronchofiberscopy for diagnosis of allergic bronchopulmonary aspergillosis. Intern Med. 1998; 36(12):865-9. DOI: 10.2169/internalmedicine.36.865. View

4.
Asano K, Hebisawa A, Ishiguro T, Takayanagi N, Nakamura Y, Suzuki J . New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis/mycosis and its validation. J Allergy Clin Immunol. 2020; 147(4):1261-1268.e5. DOI: 10.1016/j.jaci.2020.08.029. View

5.
Zeng Y, Xue X, Cai H, Zhu G, Zhu M, Wang J . Clinical Characteristics and Prognosis of Allergic Bronchopulmonary Aspergillosis: A Retrospective Cohort Study. J Asthma Allergy. 2022; 15:53-62. PMC: 8763256. DOI: 10.2147/JAA.S345427. View