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Retrospective Evaluation of Mycoplasma Genitalium Prevalence and Macrolide Resistance in a Study Cohort of Pregnant Women in Birmingham, AL, From 1997 to 2001

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Journal Sex Transm Dis
Date 2023 Jul 11
PMID 37432978
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Abstract

In a prospective study conducted in 2020 to 2021, macrolide resistance-associated mutations were found in 41% of pregnant persons in Birmingham, AL, with Mycoplasma genitalium detected. We retrospectively evaluated M. genitalium in 203 pregnant persons participating in a study conducted in 1997 to 2001 in Birmingham and adjacent areas and found a prevalence of 11% (95% confidence interval, 6.9%-15.7%), but no macrolide resistance-associated mutations.

References
1.
Jensen J, Bradshaw C, Tabrizi S, Fairley C, Hamasuna R . Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance. Clin Infect Dis. 2008; 47(12):1546-53. DOI: 10.1086/593188. View

2.
Salado-Rasmussen K, Jensen J . Mycoplasma genitalium testing pattern and macrolide resistance: a Danish nationwide retrospective survey. Clin Infect Dis. 2014; 59(1):24-30. PMC: 4305131. DOI: 10.1093/cid/ciu217. View

3.
Klein E, Milkowska-Shibata M, Tseng K, Sharland M, Gandra S, Pulcini C . Assessment of WHO antibiotic consumption and access targets in 76 countries, 2000-15: an analysis of pharmaceutical sales data. Lancet Infect Dis. 2020; 21(1):107-115. DOI: 10.1016/S1473-3099(20)30332-7. View

4.
Xiao L, Waites K, Wang H, Van Der Pol B, Ratliff A, Geisler W . Evaluation of a real-time PCR assay for detection of Mycoplasma genitalium and macrolide resistance-mediating mutations from clinical specimens. Diagn Microbiol Infect Dis. 2018; 91(2):123-125. PMC: 5970045. DOI: 10.1016/j.diagmicrobio.2018.02.002. View

5.
Lau A, Bradshaw C, Lewis D, Fairley C, Chen M, Kong F . The Efficacy of Azithromycin for the Treatment of Genital Mycoplasma genitalium: A Systematic Review and Meta-analysis. Clin Infect Dis. 2015; 61(9):1389-99. DOI: 10.1093/cid/civ644. View