CECT5716: Clinical Potential of a Probiotic Strain Isolated from Human Milk

Overview

Journal Nutrients

Date 2023 Jul 11

PMID 37432320

Authors

Metehan Ozen

Hugues Piloquet

Monika Schaubeck

Affiliations

Soon will be listed here.

Abstract

Breastfeeding provides the ideal nutrition for infants. Human milk contains a plethora of functional ingredients which foster the development of the immune system. The human milk microbiota predominantly contributes to this protective effect. This is mediated by various mechanisms, such as an antimicrobial effect, pathogen exclusion and barrier integrity, beneficial effects on the gastrointestinal microbiota, vitamin synthesis, immunity enhancement, secreted probiotic factors, and postbiotic mechanisms. Therefore, human milk is a good source for isolating probiotics for infants who cannot be exclusively breastfed. One such probiotic which was isolated from human milk is CECT5716. In this review, we give an overview of available interventional studies using CECT5716 and summarise preclinical trials in several animal models of different pathologies, which have given first insights into its mechanisms of action. We present several randomised clinical studies, which have been conducted to investigate the clinical efficacy of the CECT5716 strain in supporting the host's health.

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