» Articles » PMID: 37429860

Structural Basis of Ligand Activation and Inhibition in a Mammalian TRPV4 Ion Channel

Overview
Journal Cell Discov
Date 2023 Jul 10
PMID 37429860
Authors
Affiliations
Soon will be listed here.
Citing Articles

Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists.

Saadabadi A, Wilkman L, Rantanen M, Koivisto A, Salo-Ahen O Molecules. 2025; 30(1.

PMID: 39795157 PMC: 11722135. DOI: 10.3390/molecules30010100.


Forty sites of TRP channel regulation.

Talyzina I, Nadezhdin K, Sobolevsky A Curr Opin Chem Biol. 2024; 84:102550.

PMID: 39615427 PMC: 11788071. DOI: 10.1016/j.cbpa.2024.102550.


TRPV4 Channel in Neurological Disease: from Molecular Mechanisms to Therapeutic Potential.

Zhang F, Mehta H, Choudhary H, Islam R, Hanafy K Mol Neurobiol. 2024; 62(3):3877-3891.

PMID: 39333347 PMC: 11790740. DOI: 10.1007/s12035-024-04518-5.


Structural Pharmacology of TRPV4 Antagonists.

Fan J, Guo C, Liao D, Ke H, Lei J, Xie W Adv Sci (Weinh). 2024; 11(25):e2401583.

PMID: 38659239 PMC: 11220649. DOI: 10.1002/advs.202401583.


Piezo channels in the intestinal tract.

He H, Zhou J, Xu X, Zhou P, Zhong H, Liu M Front Physiol. 2024; 15:1356317.

PMID: 38379701 PMC: 10877011. DOI: 10.3389/fphys.2024.1356317.


References
1.
Garcia-Elias A, Mrkonjic S, Jung C, Pardo-Pastor C, Vicente R, Valverde M . The TRPV4 channel. Handb Exp Pharmacol. 2014; 222:293-319. DOI: 10.1007/978-3-642-54215-2_12. View

2.
Thorneloe K, Sulpizio A, Lin Z, Figueroa D, Clouse A, McCafferty G . N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces.... J Pharmacol Exp Ther. 2008; 326(2):432-42. DOI: 10.1124/jpet.108.139295. View

3.
Neuberger A, Nadezhdin K, Sobolevsky A . Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun. 2021; 12(1):6284. PMC: 8560856. DOI: 10.1038/s41467-021-26608-x. View

4.
Zhao C, Xie Y, Xu L, Ye F, Xu X, Yang W . Structures of a mammalian TRPM8 in closed state. Nat Commun. 2022; 13(1):3113. PMC: 9166780. DOI: 10.1038/s41467-022-30919-y. View

5.
Kwon D, Zhang F, McCray B, Feng S, Kumar M, Sullivan J . TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun. 2023; 14(1):3732. PMC: 10290081. DOI: 10.1038/s41467-023-39345-0. View