Measurement and Correlation of Solubility Data for Deferiprone in Propylene Glycol and 2-propanol at Different Temperatures

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Jul 10

PMID 37426787

Authors

Homa Rezaei

Elaheh Rahimpour

Fleming Martinez

Abolghasem Jouyban

Affiliations

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Abstract

This investigation dealt with the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol using experimental measurements and mathematical correlations. The solubility of deferiprone demonstrated a positive correlation with both temperature and propylene glycol mass fraction. Four mathematical models were employed to correlate the solid-liquid equilibrium data, and the low mean relative deviation values of less than 3.6% illustrate the good agreement of computed data with the experimental data. The apparent thermodynamic behavior of deferiprone dissolution was also investigated according to van't Hoff and Gibbs equation.

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