Twelve-year Outcomes of Bedside Laser Photocoagulation for Severe Retinopathy of Prematurity

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2023 Jul 10

PMID 37425279

Authors

Bingzhi Yang

Chaohui Lian

Ruyin Tian

Yi Chen

Song Tang

Haishan Xiang

Honghui He

Guoming Zhang

Affiliations

Soon will be listed here.

Abstract

Purpose: The purpose of this study is to evaluate the 12-year outcomes of bedside laser photocoagulation (LP) for severe retinopathy of prematurity (ROP) under sedation combined with ocular surface anesthesia in neonatal intensive care units (NICU).

Design: The study is a retrospective case series.

Methods: Infants treated with bedside LP for severe ROP from April 2009 to September 2021 were included. All LP treatments were performed under sedation and surface anesthesia at the bedside in NICU. Data were recorded for clinical and demographic characteristics, total laser spots, duration of treatment, proportion of total regression of ROP, proportion of recurrence, and adverse events.

Results: A total of 364 infants (715 eyes) were included, with a mean gestational age of 28.6 ± 2.4 weeks (range: 22.6-36.6 weeks) and a mean birth weight of 1,156.0 ± 339.0 g (range: 480-2,200 g). The mean number of laser spots was 832 ± 469, and the mean duration of treatment was 23.5 ± 5.3 min per eye. Of all the eyes, 98.3% responded to LP with complete regression of ROP. ROP recurred in 15 (2.1%) eyes after the initial LP. Additional LP was performed in seven (1.0%) eyes. No patient exhibited mistaken LP of other ocular tissues, and there were no serious ocular adverse effects. None of them needed endotracheal intubation.

Conclusions: Bedside LP treatment is effective and safe for premature infants with severe ROP under sedation and surface anesthesia in NICU, especially for infants whose general condition is unstable and not suitable for transport.

Citing Articles

A review on retinopathy of prematurity.

Rashidian P, Karami S, Salehi S Med Hypothesis Discov Innov Ophthalmol. 2025; 13(4):201-212.

PMID: 40065804 PMC: 11890260. DOI: 10.51329/mehdiophthal1511.

Reducing Intubations and Related Risks in Neonates with Retinopathy of Prematurity Undergoing Laser Photocoagulation.

Quinones Cardona V, Byrne E, Arthur N, Young M, Lavery D, Carroll A Pediatr Qual Saf. 2024; 10(1):e780.

PMID: 39734909 PMC: 11671073. DOI: 10.1097/pq9.0000000000000780.

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