Interaction Between Gut Microbiota Metabolites and Dietary Components in Lipid Metabolism and Metabolic Diseases

Overview

Journal Access Microbiol

Specialty Microbiology

Date 2023 Jul 10

PMID 37424550

Authors

Til Bahadur Basnet

Srijana Gc

Rajesh Basnet

Sadia Fatima

Mahpara Safdar

Bismillah Sehar

Ali Saad R Alsubaie

Falak Zeb

Affiliations

Soon will be listed here.

Abstract

Gut microbiota composition has caused perplexity in developing precision therapy to cure metabolic disorders. However, recent research has focused on using daily diet and natural bioactive compounds to correct gut microbiota dysbiosis and regulate host metabolism. Complex interactions between the gut microbiota and dietary compounds disrupt or integrate the gut barrier and lipid metabolism. In this review, we investigate the role of diet and bioactive natural compounds in gut microbiota dysbiosis and also the modulation of lipid metabolism by their metabolites. Recent studies have revealed that diet, natural compounds and phytochemicals impact significantly on lipid metabolism in animals and humans. These findings suggest that dietary components or natural bioactive compounds have a significant impact on microbial dysbiosis linked to metabolic diseases. The interaction between dietary components or natural bioactive compounds and gut microbiota metabolites can regulate lipid metabolism. Additionally, natural products can shape the gut microbiota and improve barrier integrity by interacting with gut metabolites and their precursors, even in unfavourable conditions, potentially contributing to the alignment of host physiology.

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