Generation of a Human Tropomyosin 1 Knockout IPSC Line

Overview

Journal Stem Cell Res

Publisher Elsevier

Specialty Cell Biology

Date 2023 Jul 9

PMID 37422949

Authors

Madison B Wilken

Jean Ann Maguire

Lea V Dungan

Alyssa Gagne

Catherine Osorio-Quintero

Elisa A Waxman

Stella T Chou

Paul Gadue

Deborah L French

Christopher S Thom

Affiliations

Soon will be listed here.

Abstract

The CHOPWT17_TPM1KOc28 iPSC line was generated to interrogate the functions of Tropomyosin 1 (TPM1) in primary human cell development. This line was reprogrammed from a previously published wild type control iPSC line.

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Leavens K, Osorio-Quintero C, Yeuteuh E, Perez-Profeta F, Dattoli A, Cardenas-Diaz F Stem Cell Res. 2024; 81():103559.

PMID: 39276530 PMC: 11719772. DOI: 10.1016/j.scr.2024.103559.

Tropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis.

Wilken M, Fonar G, Qiu R, Bennett L, Tober J, Nations C Stem Cell Reports. 2024; 19(9):1264-1276.

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