Knowledge and Attitudes of Thalassaemia Among High-risk Indigenous University Students in Bangladesh: A Pilot Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2023 Jul 7

PMID 37418439

Authors

Md Mahbub Hasan

Khaza Md Kapil Uddin

Syed Mohammad Lokman

Kallyan Chakma

Aung Chaing-U Pulu

Adnan Mannan

Enayetur Raheem

Shahed Ahmad Chowdhury

Mohammad Sorowar Hossain

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Thalassaemia is an inherited life-threatening but preventable haemoglobin disorder. South Asian countries, including Bangladesh, are the hotspots of the world's thalassaemia belt. Indigenous communities are underprivileged and vulnerable to genetic disorders, including thalassaemia. Understanding the perspectives of thalassaemia of future community leaders (indigenous university students) is critical for developing a tailor-made preventive strategy relevant to their communities. In this study, we aimed to assess the level of knowledge and attitudes towards thalassaemia among indigenous university students and determine their thalassaemia carrier status.

Methods: A cross-sectional survey was conducted among 251 tribal university students using a published questionnaire between May and October 2018. The main survey instrument consisted of 22 anonymous questions. Descriptive and inferential statistical procedures were used for data analysis.

Results: More than half (55%) of the indigenous students had never heard the term 'thalassaemia'. Around half (49%) of the marriages in their communities were consanguineous. The mean knowledge score was abysmal (4.91±2.65 out of a 12-point scale), which was not associated with the consanguinity of their parent but home districts. Multiple linear regression of demographic variables on the total knowledge score revealed that the overall knowledge is significantly associated with their home district (p< 0.05). Participants from science disciplines scored more than 1 point than their counterparts from Arts and Humanities (p = 0.08615).

Conclusions: For the first time, this study has identified knowledge gaps and misperceptions about thalassaemia among university students from indigenous communities in the southeastern region of Bangladesh. This study serves as a baseline for future interventions (premarital and prenatal screening) targeting future community leaders.

References

Hossain M, Raheem E, Sultana T, Ferdous S, Nahar N, Islam S . Thalassemias in South Asia: clinical lessons learnt from Bangladesh. Orphanet J Rare Dis. 2017; 12(1):93. PMC: 5437604. DOI: 10.1186/s13023-017-0643-z. View

Dhar-Chowdhury P, Paul K, Haque C, Hossain S, Lindsay L, Dibernardo A . Dengue seroprevalence, seroconversion and risk factors in Dhaka, Bangladesh. PLoS Negl Trop Dis. 2017; 11(3):e0005475. PMC: 5380355. DOI: 10.1371/journal.pntd.0005475. View

Taher A, Weatherall D, Cappellini M . Thalassaemia. Lancet. 2017; 391(10116):155-167. DOI: 10.1016/S0140-6736(17)31822-6. View

Ahmad R, Saleem M, Aloysious N, Yelumalai P, Mohamed N, Hassan S . Distribution of alpha thalassaemia gene variants in diverse ethnic populations in malaysia: data from the institute for medical research. Int J Mol Sci. 2013; 14(9):18599-614. PMC: 3794797. DOI: 10.3390/ijms140918599. View

Anh T, Sanchaisuriya K, Kieu G, Nguyen Tien D, Bui Thi Thu H, Sanchaisuriya P . Thalassemia and Hemoglobinopathies in an Ethnic Minority Group in Northern Vietnam. Hemoglobin. 2019; 43(4-5):249-253. DOI: 10.1080/03630269.2019.1669636. View

Nguyen N, Sanchaisuriya K, Sanchaisuriya P, Nguyen H, Phan H, Fucharoen G . Thalassemia and hemoglobinopathies in an ethnic minority group in Central Vietnam: implications to health burden and relationship between two ethnic minority groups. J Community Genet. 2017; 8(3):221-228. PMC: 5496844. DOI: 10.1007/s12687-017-0306-8. View

Alam N, Islam M, Khabir M, Suriea U, Islam M, Mohiuddin R . The scenario of knowledge, attitude and practice of the Bangladeshi population towards thalassemia prevention: A nationwide study. PLOS Glob Public Health. 2023; 2(10):e0001177. PMC: 10022238. DOI: 10.1371/journal.pgph.0001177. View

Williams T, Weatherall D . World distribution, population genetics, and health burden of the hemoglobinopathies. Cold Spring Harb Perspect Med. 2012; 2(9):a011692. PMC: 3426822. DOI: 10.1101/cshperspect.a011692. View

Huq N, Al-Amin A, Howlader S, Kabir M . Paying Out of Pocket for Healthcare in Bangladesh - A Burden on Poor?. Iran J Public Health. 2015; 44(7):1024-5. PMC: 4645756. View

10.

Hossain M, Hasan M, Raheem E, Islam M, Mosabbir A, Petrou M . Lack of knowledge and misperceptions about thalassaemia among college students in Bangladesh: a cross-sectional baseline study. Orphanet J Rare Dis. 2020; 15(1):54. PMC: 7035777. DOI: 10.1186/s13023-020-1323-y. View

11.

De Sanctis V, Kattamis C, Canatan D, Soliman A, Elsedfy H, Karimi M . β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. Mediterr J Hematol Infect Dis. 2017; 9(1):e2017018. PMC: 5333734. DOI: 10.4084/MJHID.2017.018. View

12.

Zhao P, Weng R, Wu H . Molecular Spectrum of α- and β-Thalassemia Mutations in a Large Ethnic Hakka Population in Southern China. Hemoglobin. 2018; 42(2):117-121. DOI: 10.1080/03630269.2018.1470094. View

13.

Lithanatudom P, Khampan P, Smith D, Svasti S, Fucharoen S, Kangwanpong D . The prevalence of alpha-thalassemia amongst Tai and Mon-Khmer ethnic groups residing in northern Thailand: A population-based study. Hematology. 2016; 21(8):480-5. DOI: 10.1080/10245332.2016.1148374. View

14.

Cornel M, van El C . Barriers and Facilitating Factors for Implementation of Genetic Services: A Public Health Perspective. Front Public Health. 2017; 5:195. PMC: 5543075. DOI: 10.3389/fpubh.2017.00195. View

15.

Kulaphisit M, Kampuansai J, Leecharoenkiat K, Wathikthinnakon M, Kangwanpong D, Munkongdee T . A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand. Sci Rep. 2017; 7(1):4690. PMC: 5498591. DOI: 10.1038/s41598-017-04957-2. View

16.

Shannon K, Ahmed S, Rahman H, Prue C, Khyang J, Ram M . Hemoglobin E and Glucose-6-Phosphate Dehydrogenase Deficiency and Plasmodium falciparum Malaria in the Chittagong Hill Districts of Bangladesh. Am J Trop Med Hyg. 2015; 93(2):281-6. PMC: 4530748. DOI: 10.4269/ajtmh.14-0623. View

17.

Noor F, Sultana N, Sarower Bhuyan G, Islam M, Hossain M, Sarker S . Nationwide carrier detection and molecular characterization of β-thalassemia and hemoglobin E variants in Bangladeshi population. Orphanet J Rare Dis. 2020; 15(1):15. PMC: 6961315. DOI: 10.1186/s13023-020-1294-z. View