Vaginal Microbioma and the Presence of Lactobacillus Spp. As Interferences in Female Fertility: A Review System

Overview

Journal JBRA Assist Reprod

Specialty Reproductive Medicine

Date 2023 Jul 7

PMID 37417853

Authors

Sabrina Vieira de Souza

Paula Bruno Monteiro

Gabriel Acacio de Moura

Nayara Oliveira Santos

Cristina Tonin Beneli Fontanezi

Isadora de Almeida Gomes

Clara Andrade Teixeira

Affiliations

Soon will be listed here.

Abstract

The vaginal microbiome is dominated by Lactobacillus spp. and the depletion of these microorganisms have been associated with adverse conditions that can affect women's health. Disturbance of the vaginal niche with a non-lactobacillary microbiota is associated with susceptibility to some diseases, such as obstetric alterations and infertility, resulting in failure in natural pregnancies and increased demand for assisted reproduction treatments. The present study sought to understand the influence of Lactobacillus spp. and fertility female. A systematic search was performed in the following databases: PubMed, MEDLINE, SciELO and LILACS, using the keywords: "Microbiome"; "Lactobacillus" and "Female Infertility", published in the last five years. The search resulted in 92 articles; however, 38 articles were excluded due to duplicity, 23 articles were excluded in the selection title/abstract, leaving 31 articles for full reading. In the end, 18 articles were analyzed. The studies encompassed a total of 2,011 women, using 27 types of samples to verify the composition of the microbiome. The eighteen articles that reported the microbiome of fertile women were constituted by a dominance of Lactobacillus spp. who joined to positive predictive outcomes in reproduction, while infertile women showed a dysbiotic profile. Therefore, analyzing bacterial patterns would allow a personalized diagnosis, which could favor personalized therapy for prevention and treatment of certain diseases.

Citing Articles

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