Dose-dependent Localisation and Potential for Therapy of F(ab')2 Fragments Against CEA Studied in a Human Tumour Xenograft Model

Overview

Journal Br J Cancer

Specialty Oncology

Date 1986 Aug 1

PMID 3741770

Citations 6

Authors

G T Rogers

P J Harwood

R B Pedley

J Boden

K D Bagshawe

Affiliations

Soon will be listed here.

Citing Articles

Microbial cytosine deaminase is a programmable anticancer prodrug mediating enzyme: antibody, and gene directed enzyme prodrug therapy.

El-Sayed A, Mohamed N, Yassin M, Amer M, El-Sharkawy R, El-Sayed N Heliyon. 2022; 8(9):e10660.

PMID: 36164544 PMC: 9508425. DOI: 10.1016/j.heliyon.2022.e10660.

Antibody-directed enzyme prodrug therapy.

Bagshawe K Clin Pharmacokinet. 1994; 27(5):368-76.

PMID: 7851054 DOI: 10.2165/00003088-199427050-00004.

Effect of dose escalation of a monoclonal anti-CEA IgG on tumour localisation and tissue distribution in nude mice xenografted with human colon carcinoma.

Rogers G, Pedley R, Boden J, Harwood P, Bagshawe K Cancer Immunol Immunother. 1986; 23(2):107-12.

PMID: 3779712 PMC: 11038251. DOI: 10.1007/BF00199815.

Theoretical considerations for improving tumour targeting.

Thomas G, Chappell M, Dykes P, Ramsden D, Godfrey K, Ellis J Br J Cancer Suppl. 1990; 10:70-3.

PMID: 2383483 PMC: 2149514.

Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model.

Sharma S, Bagshawe K, Burke P, BODEN R, Rogers G Br J Cancer. 1990; 61(5):659-62.

PMID: 2337503 PMC: 1971605. DOI: 10.1038/bjc.1990.149.

References

Mach J, Carrel S, Forni M, Ritschard J, Donath A, Alberto P . Tumor localization of radio-labeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation. N Engl J Med. 1980; 303(1):5-10. DOI: 10.1056/NEJM198007033030102. View

Wilbanks T, Peterson J, Miller S, Kaufman L, Ortendahl D, Ceriani R . Localization of mammary tumors in vivo with 131I-labeled Fab fragments of antibodies against mouse mammary epithelial (MME) antigens. Cancer. 1981; 48(8):1768-75. DOI: 10.1002/1097-0142(19811015)48:8<1768::aid-cncr2820480813>3.0.co;2-p. View

Lamoyi E, Nisonoff A . Preparation of F(ab')2 fragments from mouse IgG of various subclasses. J Immunol Methods. 1983; 56(2):235-43. DOI: 10.1016/0022-1759(83)90415-5. View

Wahl R, Parker C, PHILPOTT G . Improved radioimaging and tumor localization with monoclonal F(ab')2. J Nucl Med. 1983; 24(4):316-25. View

Buchegger F, Haskell C, Schreyer M, SCAZZIGA B, Randin S, Carrel S . Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice. J Exp Med. 1983; 158(2):413-27. PMC: 2187333. DOI: 10.1084/jem.158.2.413. View

Rogers G, Boden J, Harwood P, Pedley R, RAWLINS G, Bagshawe K . Dose dependent localisation of a monoclonal F(ab')2 fragment against CEA in the mouse xenograft model. Eur J Cancer Clin Oncol. 1986; 22(6):709-10. DOI: 10.1016/0277-5379(86)90170-7. View

Larson S, Carrasquillo J, Reynolds J . Radioimmunodetection and radioimmunotherapy. Cancer Invest. 1984; 2(5):363-81. DOI: 10.3109/07357908409040313. View

Begent R . Recent advances in tumour imaging. Use of radiolabelled antitumour antibodies. Biochim Biophys Acta. 1985; 780(2):151-66. DOI: 10.1016/0304-419x(84)90003-9. View

Harwood P, Boden J, Pedley R, Rawlins G, Rogers G, Bagshawe K . Comparative tumour localization of antibody fragments and intact IgG in nude mice bearing a CEA-producing human colon tumour xenograft. Eur J Cancer Clin Oncol. 1985; 21(12):1515-22. DOI: 10.1016/0277-5379(85)90247-0. View

10.

Rogers G, Harwood P, Pedley R, Boden J, Rawlins G, Bagshawe K . Dynamics of monoclonal antibody distribution and prolonged tumour localisation in nude mice bearing a human CEA-producing colon carcinoma xenograft. Tumour Biol. 1986; 6(5):453-63. View

11.

Zalcberg J, Thompson C, Lichtenstein M, McKenzie I . Tumor immunotherapy in the mouse with the use of 131I-labeled monoclonal antibodies. J Natl Cancer Inst. 1984; 72(3):697-704. View