The NLRP3 Inflammasome in Viral Infection (Review)

Overview

Journal Mol Med Rep

Specialty Molecular Biology

Date 2023 Jul 7

PMID 37417336

Authors

Qiaoli Zheng

Chunting Hua

Qichang Liang

Hao Cheng

Affiliations

Soon will be listed here.

Abstract

The interplay between pathogen and host determines the immune response during viral infection. The Nod‑like receptor (NLR) protein 3 inflammasome is a multiprotein complex that induces the activation of inflammatory caspases and the release of IL‑1β, which play an important role in the innate immune responses. In the present review, the mechanisms of the NLR family pyrin domain containing 3 inflammasome activation and its dysregulation in viral infection were addressed.

Citing Articles

MicroRNAs Regulate the Expression of Genes Related to the Innate Immune and Inflammatory Response in Rabbits Infected with GI.1 and GI.2 Genotypes.

Ostrycharz-Jasek E, Fitzner A, Siennicka A, Budkowska M, Hukowska-Szematowicz B Int J Mol Sci. 2024; 25(17).

PMID: 39273479 PMC: 11394960. DOI: 10.3390/ijms25179531.

SARS-CoV-2: A Glance at the Innate Immune Response Elicited by Infection and Vaccination.

Manfrini N, Notarbartolo S, Grifantini R, Pesce E Antibodies (Basel). 2024; 13(1).

PMID: 38390874 PMC: 10885122. DOI: 10.3390/antib13010013.

Korean Chestnut Honey Suppresses HSV-1 Infection by Regulating the ROS-NLRP3 Inflammasome Pathway.

Kwon E, Kim Y, Kim B, Kim S, Na S, Go Y Antioxidants (Basel). 2023; 12(11).

PMID: 38001788 PMC: 10669648. DOI: 10.3390/antiox12111935.

Editorial: The role of inflammasome in viral infection.

Wan P, Zhang Y, Pan P, Li Y Front Cell Infect Microbiol. 2023; 13:1260013.

PMID: 37608846 PMC: 10441574. DOI: 10.3389/fcimb.2023.1260013.

References

Chou W, Jha S, Linhoff M, Ting J . The NLR gene family: from discovery to present day. Nat Rev Immunol. 2023; 23(10):635-654. PMC: 11171412. DOI: 10.1038/s41577-023-00849-x. View

Xu J, Zhou Z, Zheng Y, Yang S, Huang K, Li H . Roles of inflammasomes in viral myocarditis. Front Cell Infect Microbiol. 2023; 13:1149911. PMC: 10225676. DOI: 10.3389/fcimb.2023.1149911. View

Bedoya F, Sandler L, Harton J . Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions. J Immunol. 2007; 178(6):3837-45. DOI: 10.4049/jimmunol.178.6.3837. View

Agostini L, Martinon F, Burns K, McDermott M, Hawkins P, Tschopp J . NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity. 2004; 20(3):319-25. DOI: 10.1016/s1074-7613(04)00046-9. View

Lamkanfi M, Denecker G, Kalai M, DHondt K, Meeus A, Declercq W . INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. J Biol Chem. 2004; 279(50):51729-38. DOI: 10.1074/jbc.M407891200. View

Shrivastava G, Visoso-Carvajal G, Garcia-Cordero J, Leon-Juarez M, Chavez-Munguia B, Lopez T . Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome. Front Immunol. 2020; 11:352. PMC: 7076137. DOI: 10.3389/fimmu.2020.00352. View

Rathinam V, Zhao Y, Shao F . Innate immunity to intracellular LPS. Nat Immunol. 2019; 20(5):527-533. PMC: 7668400. DOI: 10.1038/s41590-019-0368-3. View

Hornung V, Bauernfeind F, Halle A, Samstad E, Kono H, Rock K . Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008; 9(8):847-56. PMC: 2834784. DOI: 10.1038/ni.1631. View

Naseer N, Zhang J, Bauer R, Constant D, Nice T, Brodsky I . Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells. Infect Immun. 2022; 90(7):e0066321. PMC: 9302179. DOI: 10.1128/iai.00663-21. View

10.

Devant P, Kagan J . Molecular mechanisms of gasdermin D pore-forming activity. Nat Immunol. 2023; 24(7):1064-1075. DOI: 10.1038/s41590-023-01526-w. View

11.

Wang W, Li G, Wu D, Luo Z, Pan P, Tian M . Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion. Nat Commun. 2018; 9(1):106. PMC: 5760693. DOI: 10.1038/s41467-017-02645-3. View

12.

Pelegrin P . P2X7 receptor and the NLRP3 inflammasome: Partners in crime. Biochem Pharmacol. 2020; 187:114385. DOI: 10.1016/j.bcp.2020.114385. View

13.

Cassel S, Eisenbarth S, Iyer S, Sadler J, Colegio O, Tephly L . The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A. 2008; 105(26):9035-40. PMC: 2449360. DOI: 10.1073/pnas.0803933105. View

14.

Schroder K, Tschopp J . The inflammasomes. Cell. 2010; 140(6):821-32. DOI: 10.1016/j.cell.2010.01.040. View

15.

Wang H, Lei X, Xiao X, Yang C, Lu W, Huang Z . Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome. Cell Rep. 2015; 12(1):42-48. DOI: 10.1016/j.celrep.2015.05.047. View

16.

Li J, Hu L, Liu Y, Huang L, Mu Y, Cai X . DDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome Activation. J Immunol. 2015; 195(12):5732-49. DOI: 10.4049/jimmunol.1501606. View

17.

Guo Y, Gu D, Huang T, Li A, Zhou Y, Kang X . Salmonella Enteritidis T1SS protein SiiD inhibits NLRP3 inflammasome activation via repressing the mtROS-ASC dependent pathway. PLoS Pathog. 2023; 19(5):e1011381. PMC: 10194869. DOI: 10.1371/journal.ppat.1011381. View

18.

Barlan A, Danthi P, Wiethoff C . Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome. Virology. 2011; 412(2):306-14. PMC: 3060956. DOI: 10.1016/j.virol.2011.01.019. View

19.

Farag N, Breitinger U, Breitinger H, El Azizi M . Viroporins and inflammasomes: A key to understand virus-induced inflammation. Int J Biochem Cell Biol. 2020; 122:105738. PMC: 7102644. DOI: 10.1016/j.biocel.2020.105738. View

20.

Cabral A, Cabral J, Wang A, Zhang Y, Liang H, Nikbakht D . Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation. Commun Biol. 2023; 6(1):578. PMC: 10229695. DOI: 10.1038/s42003-023-04817-y. View