CD7 Protein Plays a Crucial Role in T Cell Infiltration in Tumors

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Jul 7

PMID 37416646

Authors

Binjie Sheng

Kailu Zhang

Shuaiyu Tian

Renyuxue Ma

Zixuan Li

Hai Wu

Tian Wang

Licui Jiang

Fengtao You

Gangli An

Huimin Meng

Lin Yang

Xin Liu

Affiliations

Soon will be listed here.

Abstract

CD7 protein as a target is being used to treat CD7 lymphoma; however, the role of CD7 in the hematopoietic system remains largely unknown. Therefore, we evaluated the effects of CD7 KO in mice. The differentiation of the hematopoietic system in the bone marrow and the number of various cell types in the thymus and spleen did not differ between CD7 KO and WT mice. After subcutaneous inoculation of B16-F10 melanoma cells, tumors from CD7 KO mice grew more rapidly, and the proportion of CD8 T cells in the spleen and tumors decreased. In vitro, the infiltration and adhesion of CD8 T cells from the spleen of CD7 KO mice were weakened. Blocking CD7 in normal T cells did not alter the migration and infiltration, but in Jurkat, CCRF-CEM, and KG-1a tumor cell lines, migration and invasion were significantly reduced after blocking CD7. Therefore, CD7 does not affect hematopoietic system development but plays a crucial role in T cell infiltration into tumors.

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