» Articles » PMID: 37415797

Effect of Genetic Variants in and on Facial Morphology of Koreans

Overview
Specialty Forensic Sciences
Date 2023 Jul 7
PMID 37415797
Authors
Affiliations
Soon will be listed here.
Abstract

Key Points: GWAS of normal facial variation in the Korean population was conducted using a Korean genome chip.Previously reported genetic signals associated with , , and loci were replicated in the Korean populations.Genetic signals in and loci were identified as novel variants for corresponding facial features.

References
1.
Kim Y, Go M, Hu C, Bum Hong C, Kim Y, Lee J . Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet. 2011; 43(10):990-5. DOI: 10.1038/ng.939. View

2.
Ullah K, Zubia E, Narayan M, Yang J, Xu G . Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset. FEBS J. 2018; 286(11):2018-2034. DOI: 10.1111/febs.14708. View

3.
Adhikari K, Fuentes-Guajardo M, Quinto-Sanchez M, Mendoza-Revilla J, Chacon-Duque J, Acuna-Alonzo V . A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation. Nat Commun. 2016; 7:11616. PMC: 4874031. DOI: 10.1038/ncomms11616. View

4.
Graham A . Development of the pharyngeal arches. Am J Med Genet A. 2003; 119A(3):251-6. DOI: 10.1002/ajmg.a.10980. View

5.
Lee M, Shaffer J, Leslie E, Orlova E, Carlson J, Feingold E . Genome-wide association study of facial morphology reveals novel associations with FREM1 and PARK2. PLoS One. 2017; 12(4):e0176566. PMC: 5404842. DOI: 10.1371/journal.pone.0176566. View