Tumor Organoid Model of Colorectal Cancer (Review)

Overview

Journal Oncol Lett

Specialty Oncology

Date 2023 Jul 7

PMID 37415635

Authors

Chi Yang

Wangwen Xiao

Rui Wang

Yan Hu

Ke Yi

Xuan Sun

Guanghui Wang

Xiaohui Xu

Affiliations

Soon will be listed here.

Abstract

The establishment of self-organizing 'mini-gut' organoid models has brought about a significant breakthrough in biomedical research. Patient-derived tumor organoids have emerged as valuable tools for preclinical studies, offering the retention of genetic and phenotypic characteristics of the original tumor. These organoids have applications in various research areas, including modelling, drug discovery and personalized medicine. The present review provided an overview of intestinal organoids, focusing on their unique characteristics and current understanding. The progress made in colorectal cancer (CRC) organoid models was then delved into, discussing their role in drug development and personalized medicine. For instance, it has been indicated that patient-derived tumor organoids are able to predict response to irinotecan-based neoadjuvant chemoradiotherapy. Furthermore, the limitations and challenges associated with current CRC organoid models were addressed, along with proposed strategies for enhancing their utility in future basic and translational research.

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