Renal Handling of Phosphate in the First Six Months of Life

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1986 Jul 1

PMID 3740907

Citations 13

Authors

L Bistarakis

I Voskaki

J Lambadaridis

H Sereti

S Sbyrakis

Affiliations

Soon will be listed here.

Abstract

Indices of renal excretion and reabsorption of phosphate were studied in 20 neonatal infants, 20 infants aged 3 months, and 20 infants aged 6 months. All subjects were normal and were fed a modified formula enriched with vitamin D. In neonatal infants all indices of phosphate excretion were found to be significantly lower and those of phosphate reabsorption significantly higher than in older infants. Phosphate excretion gradually increased with age, while its reabsorption decreased. The positive correlation between serum phosphorus and renal threshold phosphate concentration (TmP/GFR) and the negative correlation between phosphorus excretion index and TmP/GFR found in this study shows that in young infants as in adults TmP/GFR is the principal determinant of renal phosphate homeostasis. Among the many indices of renal phosphate handling in use TmP/GFR is the best for studies of phosphorus or calcium metabolism disorders, or both, especially in the first three months of life.

Citing Articles

Urinary excretion of calcium, phosphate, magnesium, and uric acid in healthy infants and young children. Influence of feeding practices in early infancy.

Peris Vidal A, Ferrando Monleon S, Marin Serra J, Quinones-Torrelo C, Hervas Andres A, Fons Moreno J Pediatr Nephrol. 2023; 39(3):761-770.

PMID: 37755464 DOI: 10.1007/s00467-023-06145-z.

Asia-Pacific Consensus Recommendations on X-Linked Hypophosphatemia: Diagnosis, Multidisciplinary Management, and Transition From Pediatric to Adult Care.

Munns C, Yoo H, Jalaludin M, Vasanwala R, Chandran M, Rhee Y JBMR Plus. 2023; 7(6):e10744.

PMID: 37283655 PMC: 10241092. DOI: 10.1002/jbm4.10744.

Interdisciplinary management of FGF23-related phosphate wasting syndromes: a Consensus Statement on the evaluation, diagnosis and care of patients with X-linked hypophosphataemia.

Trombetti A, Al-Daghri N, Brandi M, Cannata-Andia J, Cavalier E, Chandran M Nat Rev Endocrinol. 2022; 18(6):366-384.

PMID: 35484227 DOI: 10.1038/s41574-022-00662-x.

Health Care Transition From Pediatric- to Adult-Focused Care in X-linked Hypophosphatemia: Expert Consensus.

Dahir K, Dhaliwal R, Simmons J, Imel E, Gottesman G, Mahan J J Clin Endocrinol Metab. 2021; 107(3):599-613.

PMID: 34741521 PMC: 8852209. DOI: 10.1210/clinem/dgab796.

Developmental Changes in Phosphate Homeostasis.

MacDonald T, Saurette M, Beggs M, Alexander R Rev Physiol Biochem Pharmacol. 2021; 179:117-138.

PMID: 33398502 DOI: 10.1007/112_2020_52.

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