Associations of Vitamin D-related Single Nucleotide Polymorphisms with Post-stroke Depression Among Ischemic Stroke Population

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2023 Jul 5

PMID 37404714

Authors

Dongren Sun

Mingyu Song

Chang Zeng

Hengshu Chen

Jingyuan Zhang

Fan Liu

Shihang Luo

Qiao Liao

Yeqing Xiao

Weiye Xu

Danfeng Zeng

Zheren Tan

Fafa Tian

Xia Huang

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the relationship between single nucleotide polymorphisms (SNPs) related to vitamin D (VitD) metabolism and post-stroke depression (PSD) in patients with ischemic stroke.

Methods: A total of 210 patients with ischemic stroke were enrolled at the Department of Neurology in Xiangya Hospital, Central South University, from July 2019 to August 2021. SNPs in the VitD metabolic pathway (, , , and ) were genotyped using the SNPscan multiplex SNP typing kit. Demographic and clinical data were collected using a standardized questionnaire. Multiple genetic models including dominant, recessive, and over-dominant models were utilized to analyze the associations between SNPs and PSD.

Results: In the dominant, recessive, and over-dominant models, no significant association was observed between the selected SNPs in the and genes and PSD. However, univariate and multivariate logistic regression analysis revealed that the rs10877012 G/G genotype was associated with a decreased risk of PSD (OR: 0.41, 95% CI: 0.18-0.92, = 0.030 and OR: 0.42, 95% CI: 0.18-0.98, = 0.040, respectively). Furthermore, haplotype association analysis indicated that rs11568820-rs1544410-rs2228570-rs7975232-rs731236 CCGAA haplotype in the gene was associated with a reduced risk of PSD (OR: 0.14, 95% CI: 0.03-0.65, = 0.010), whereas no significant association was observed between haplotypes in the and genes and PSD.

Conclusion: Our findings suggest that the polymorphisms of VitD metabolic pathway genes and may be associated with PSD in patients with ischemic stroke.

Citing Articles

Putative Pharmacological Depression and Anxiety-Related Targets of Calcitriol Explored by Network Pharmacology and Molecular Docking.

Kouba B, Alte G, Rodrigues A Pharmaceuticals (Basel). 2024; 17(7).

PMID: 39065743 PMC: 11280388. DOI: 10.3390/ph17070893.

References

Bahrami A, Sadeghnia H, Tabatabaeizadeh S, Bahrami-Taghanaki H, Behboodi N, Esmaeili H . Genetic and epigenetic factors influencing vitamin D status. J Cell Physiol. 2017; 233(5):4033-4043. DOI: 10.1002/jcp.26216. View

Hasan M, Oster M, Reyer H, Ponsuksili S, Murani E, Wolf P . Tissue-Wide Expression of Genes Related to Vitamin D Metabolism and FGF23 Signaling following Variable Phosphorus Intake in Pigs. Metabolites. 2022; 12(8). PMC: 9413461. DOI: 10.3390/metabo12080729. View

Yang W, Ma F, Wang L, He X, Zhang H, Zheng J . The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population. Brain Behav. 2019; 10(2):e01503. PMC: 7010572. DOI: 10.1002/brb3.1503. View

Fu G, Lin D, Zhang M, Bikle D, Shackleton C, Miller W . Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol. 1998; 11(13):1961-70. DOI: 10.1210/mend.11.13.0035. View

Glocke M, Lang F, Schaeffeler E, Lang T, Schwab M, Lang U . Impact of vitamin D receptor VDR rs2228570 polymorphism in oldest old. Kidney Blood Press Res. 2013; 37(4-5):311-22. DOI: 10.1159/000350159. View

Ding N, Yu R, Subramaniam N, Sherman M, Wilson C, Rao R . A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell. 2013; 153(3):601-13. PMC: 3673534. DOI: 10.1016/j.cell.2013.03.028. View

Curtin F, Schulz P . Multiple correlations and Bonferroni's correction. Biol Psychiatry. 1998; 44(8):775-7. DOI: 10.1016/s0006-3223(98)00043-2. View

Postolache T, Akram F, Lee E, Lowry C, Stiller J, Brenner L . Increased brain vitamin D receptor expression and decreased expression of cathelicidin antimicrobial peptide in individuals who died by suicide. J Psychiatr Res. 2020; 125:75-84. DOI: 10.1016/j.jpsychires.2020.02.027. View

Wang Y, Zhang M, Huang W, Wu S, Wang M, Tang X . Polymorphisms in Toll-Like Receptor 10 and Tuberculosis Susceptibility: Evidence from Three Independent Series. Front Immunol. 2018; 9:309. PMC: 5829065. DOI: 10.3389/fimmu.2018.00309. View

10.

Mei F, Wu Y, Ding G, Pan F, Chen L, Wu J . Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with post-stroke depression risk and antidepressant treatment response in Han Chinese. J Pak Med Assoc. 2018; 68(7):888-892. View

11.

Brouwer-Brolsma E, Dhonukshe-Rutten R, van Wijngaarden J, van der Zwaluw N, Sohl E, Int Veld P . Low vitamin D status is associated with more depressive symptoms in Dutch older adults. Eur J Nutr. 2015; 55(4):1525-34. PMC: 4875055. DOI: 10.1007/s00394-015-0970-6. View

12.

Paolucci S, Grasso M, Antonucci G, Troisi E, Morelli D, Coiro P . One-year follow-Up in stroke patients discharged from rehabilitation hospital. Cerebrovasc Dis. 2000; 10(1):25-32. DOI: 10.1159/000016021. View

13.

Kempinska-Podhorodecka A, Adamowicz M, Chmielarz M, Janik M, Milkiewicz P, Milkiewicz M . Vitamin-D Receptor-Gene Polymorphisms Affect Quality of Life in Patients with Autoimmune Liver Diseases. Nutrients. 2020; 12(8). PMC: 7469002. DOI: 10.3390/nu12082244. View

14.

Duan L, Xue Z, Ji H, Zhang D, Wang Y . Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis. Gene. 2018; 678:361-369. DOI: 10.1016/j.gene.2018.08.056. View

15.

Saccone D, Asani F, Bornman L . Regulation of the vitamin D receptor gene by environment, genetics and epigenetics. Gene. 2015; 561(2):171-80. DOI: 10.1016/j.gene.2015.02.024. View

16.

Zeng Y, Cheng H, Cheng L, Huang G, Chen Y, Tang W . Comparison of poststroke depression between acute ischemic and hemorrhagic stroke patients. Int J Geriatr Psychiatry. 2020; 36(4):493-499. DOI: 10.1002/gps.5444. View

17.

Han B, Lyu Y, Sun H, Wei Y, He J . Low serum levels of vitamin D are associated with post-stroke depression. Eur J Neurol. 2014; 22(9):1269-74. DOI: 10.1111/ene.12607. View

18.

Li X, Wang J, Xu A, Huang J, Meng L, Huang R . Apolipoprotein E polymorphisms increase the risk of post-stroke depression. Neural Regen Res. 2017; 11(11):1790-1796. PMC: 5204235. DOI: 10.4103/1673-5374.194748. View

19.

Lin H, Zhu X, Long J, Chen Y, Xie Y, Liao M . HIPK2 polymorphisms rs2058265, rs6464214, and rs7456421 were associated with kidney stone disease in Chinese males not females. Gene. 2018; 653:51-56. DOI: 10.1016/j.gene.2018.02.020. View

20.

Gu Y, Zhu Z, Luan X, He J . Vitamin D status and its association with season, depression in stroke. Neurosci Lett. 2018; 690:99-105. DOI: 10.1016/j.neulet.2018.09.046. View