Symmetrical Distributions of Aminoacyl-tRNA Synthetases During the Evolution of the Genetic Code

Overview

Journal Theory Biosci

Specialty Biology

Date 2023 Jul 4

PMID 37402895

Authors

Marco V Jose

Juan R Bobadilla

Gabriel S Zamudio

Savio Torres de Farias

Affiliations

Soon will be listed here.

Abstract

In this work, we formulate the following question: How the distribution of aminoacyl-tRNA synthetases (aaRSs) went from an ancestral bidirectional gene (mirror symmetry) to the symmetrical distribution of aaRSs in a six-dimensional hypercube of the Standard Genetic Code (SGC)? We assume a primeval RNY code, two Extended Genetic RNA codes type 1 and 2, and the SGC. We outline the types of symmetries of the distribution of aaRSs in each code. The symmetry groups of aaRSs in each code are described, until the symmetries of the SGC display a mirror symmetry. Considering both Extended RNA codes the 20 aaRSs were already present before the Last Universal Ancestor. These findings reveal intricacies in the diversification of aaRSs accompanied by the evolution of the genetic code.

Citing Articles

Groups of Symmetries of the Two Classes of Synthetases in the Four-Dimensional Hypercubes of the Extended Code Type II.

Jose M, Morgado E, Bobadilla J Life (Basel). 2023; 13(10).

PMID: 37895385 PMC: 10607949. DOI: 10.3390/life13102002.

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