Kidney Complications Associated with COVID-19 Infection and Vaccination in Children and Adolescents: a Brief Review

Overview

Journal Clin Exp Pediatr

Specialty Pediatrics

Date 2023 Jul 4

PMID 37402469

Authors

Hee Sun Baek

Min Hyun Cho

Affiliations

Soon will be listed here.

Abstract

Coronavirus disease 2019 (COVID-19) has spread considerably across the globe, affecting numerous children and adolescents besides adults. Despite its relatively lower incidence rates in children and adolescents than in adults, some infected children and adolescents exhibit a severe postinflammatory response known as multisystem inflammatory syndrome in children, followed by acute kidney injury, a common complication. Meanwhile, few reports have been available regarding kidney complications such as idiopathic nephrotic syndrome and other glomerulopathies associated with COVID-19 infection and vaccination in children and adolescents. However, the morbidity and mortality of these complications are not exceptionally high; more importantly, causality has yet to be clearly established. Finally, vaccine hesitancy in these age groups should be addressed, considering the strong evidence of COVID-19 vaccine safety and efficacy.

Citing Articles

Clinical considerations and practical issues of kidney complications in children after COVID-19 infection or vaccination.

Jung J, Lee J Clin Exp Pediatr. 2023; 67(1):35-36.

PMID: 37986565 PMC: 10764664. DOI: 10.3345/cep.2023.01074.

COVID-19 infection and vaccination among children.

Kleebayoon A, Wiwanitkit V Clin Exp Pediatr. 2023; 66(12):531-532.

PMID: 37654170 PMC: 10694554. DOI: 10.3345/cep.2023.00899.

References

Chiodini B, Bellotti A, Morello W, Bulgaro C, Farella I, Giordano M . Relapse rate in children with nephrotic syndrome during the SARS-CoV-2 pandemic. Pediatr Nephrol. 2022; 38(4):1139-1146. PMC: 9383657. DOI: 10.1007/s00467-022-05702-2. View

Morello W, Vianello F, Bulgaro C, Montini G . Epidemiology, severity, and risk of SARS-CoV-2-related relapse in children and young adults affected by idiopathic nephrotic syndrome: a retrospective observational cohort study. Pediatr Nephrol. 2022; 38(4):1159-1166. PMC: 9510541. DOI: 10.1007/s00467-022-05736-6. View

H Abdel-Qader D, Hazza Alkhatatbeh I, Hayajneh W, Annab H, Al Meslamani A, Elmusa R . IgA nephropathy in a pediatric patient after receiving the first dose of Pfizer-BioNTech COVID-19 vaccine. Vaccine. 2022; 40(18):2528-2530. PMC: 8942577. DOI: 10.1016/j.vaccine.2022.03.003. View

Gonzalez-Dambrauskas S, Vasquez-Hoyos P, Camporesi A, Diaz-Rubio F, Pineres-Olave B, Fernandez-Sarmiento J . Pediatric Critical Care and COVID-19. Pediatrics. 2020; 146(3). DOI: 10.1542/peds.2020-1766. View

Horino T, Sawamura D, Inotani S, Ishihara M, Komori M, Ichii O . Newly diagnosed IgA nephropathy with gross haematuria following COVID-19 vaccination. QJM. 2021; 115(1):28-29. PMC: 8690244. DOI: 10.1093/qjmed/hcab305. View

. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Int. 2021; 100(4S):S1-S276. DOI: 10.1016/j.kint.2021.05.021. View

Saygili S, Canpolat N, Cicek R, Agbas A, Yilmaz E, Sakalli A . Clinical and subclinical acute kidney injury in children with mild-to-moderate COVID-19. Pediatr Res. 2022; 93(3):654-660. PMC: 9178933. DOI: 10.1038/s41390-022-02124-6. View

Gungor T, Yazilitas F, Cakici E, Karakaya D, Bulbul M . Relapse of Idiopathic Nephrotic Syndrome After SARS-CoV-2 Vaccination: Two Case Reports. J Paediatr Child Health. 2022; 58(5):939-940. DOI: 10.1111/jpc.15977. View

Alhosaini M . A Case of Minimal Change Disease after SARS-CoV-2 Vaccination under the Age of 18. Avicenna J Med. 2022; 12(1):31-33. PMC: 9110102. DOI: 10.1055/s-0042-1743209. View

10.

Chopra S, Saha A, Kumar V, Thakur A, Pemde H, Kapoor D . Acute Kidney Injury in Hospitalized Children with COVID19. J Trop Pediatr. 2021; 67(2). PMC: 8195178. DOI: 10.1093/tropej/fmab037. View

11.

Lipton M, Mahajan R, Kavanagh C, Shen C, Batal I, Dogra S . AKI in COVID-19-Associated Multisystem Inflammatory Syndrome in Children (MIS-C). Kidney360. 2022; 2(4):611-618. PMC: 8791329. DOI: 10.34067/KID.0005372020. View

12.

Frenck Jr R, Klein N, Kitchin N, Gurtman A, Absalon J, Lockhart S . Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents. N Engl J Med. 2021; 385(3):239-250. PMC: 8174030. DOI: 10.1056/NEJMoa2107456. View

13.

Feldstein L, Rose E, Horwitz S, Collins J, Newhams M, Son M . Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020; 383(4):334-346. PMC: 7346765. DOI: 10.1056/NEJMoa2021680. View

14.

Negrea L, Rovin B . Gross hematuria following vaccination for severe acute respiratory syndrome coronavirus 2 in 2 patients with IgA nephropathy. Kidney Int. 2021; 99(6):1487. PMC: 7987498. DOI: 10.1016/j.kint.2021.03.002. View

15.

Udagawa T, Motoyoshi Y . Macroscopic hematuria in two children with IgA nephropathy remission following Pfizer COVID-19 vaccination. Pediatr Nephrol. 2022; 37(7):1693-1694. PMC: 8930192. DOI: 10.1007/s00467-022-05517-1. View

16.

Basalely A, Gurusinghe S, Schneider J, Shah S, Siegel L, Pollack G . Acute kidney injury in pediatric patients hospitalized with acute COVID-19 and multisystem inflammatory syndrome in children associated with COVID-19. Kidney Int. 2021; 100(1):138-145. PMC: 7927648. DOI: 10.1016/j.kint.2021.02.026. View

17.

Okada M, Kikuchi E, Nagasawa M, Oshiba A, Shimoda M . An adolescent girl diagnosed with IgA nephropathy following the first dose of the COVID-19 vaccine. CEN Case Rep. 2022; 11(3):376-379. PMC: 8812345. DOI: 10.1007/s13730-021-00679-7. View

18.

Morgans H, Schuster J, Warady B . Pediatric Vaccine Hesitancy and COVID-19. Am J Kidney Dis. 2022; 81(1):13-14. PMC: 9630134. DOI: 10.1053/j.ajkd.2022.07.003. View

19.

Nadim M, Forni L, Mehta R, Connor Jr M, Liu K, Ostermann M . COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol. 2020; 16(12):747-764. PMC: 7561246. DOI: 10.1038/s41581-020-00356-5. View

20.

Fireizen Y, Shahriary C, Imperial M, Randhawa I, Nianiaris N, Ovunc B . Pediatric P-ANCA vasculitis following COVID-19. Pediatr Pulmonol. 2021; 56(10):3422-3424. PMC: 8441809. DOI: 10.1002/ppul.25612. View