Natural Compounds Targeting Mitochondrial Dysfunction: Emerging Therapeutics for Target Organ Damage in Hypertension

Overview

Journal Front Pharmacol

Date 2023 Jul 3

PMID 37397478

Authors

Xiaolin Liao

Yuanshan Han

Ying He

Jianjun Liu

Yuhong Wang

Affiliations

Soon will be listed here.

Abstract

Hypertension generally causes target organ damage (TOD) in the heart, brain, kidney, and blood vessels. This can result in atherosclerosis, plaque formation, cardiovascular and cerebrovascular events, and renal failure. Recent studies have indicated that mitochondrial dysfunction is crucial in hypertensive target organ damage. Consequently, mitochondria-targeted therapies attract increasing attention. Natural compounds are valuable resources for drug discovery and development. Many studies have demonstrated that natural compounds can ameliorate mitochondrial dysfunction in hypertensive target organ damage. This review examines the contribution of mitochondrial dysfunction to the development of target organ damage in hypertension. Moreover, it summarizes therapeutic strategies based on natural compounds that target mitochondrial dysfunction, which may be beneficial for preventing and treating hypertensive target organ damage.

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