Metabolomics in Aging Research: Aging Markers from Organs

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2023 Jul 3

PMID 37397261

Authors

Weicheng Fang

Shuxin Chen

Xuejiao Jin

Shenkui Liu

Xiuling Cao

Beidong Liu

Affiliations

Soon will be listed here.

Abstract

Metabolism plays an important role in regulating aging at several levels, and metabolic reprogramming is the main driving force of aging. Due to the different metabolic needs of different tissues, the change trend of metabolites during aging in different organs and the influence of different levels of metabolites on organ function are also different, which makes the relationship between the change of metabolite level and aging more complex. However, not all of these changes lead to aging. The development of metabonomics research has opened a door for people to understand the overall changes in the metabolic level in the aging process of organisms. The omics-based "aging clock" of organisms has been established at the level of gene, protein and epigenetic modifications, but there is still no systematic summary at the level of metabolism. Here, we reviewed the relevant research published in the last decade on aging and organ metabolomic changes, discussed several metabolites with high repetition rate, and explained their role , hoping to find a group of metabolites that can be used as metabolic markers of aging. This information should provide valuable information for future diagnosis or clinical intervention of aging and age-related diseases.

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References

Camacho-Pereira J, Tarrago M, Chini C, Nin V, Escande C, Warner G . CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016; 23(6):1127-1139. PMC: 4911708. DOI: 10.1016/j.cmet.2016.05.006. View

Chakraborty J, Stover P . Deoxyuracil in DNA in health and disease. Curr Opin Clin Nutr Metab Care. 2020; 23(4):247-252. PMC: 7347158. DOI: 10.1097/MCO.0000000000000660. View

Adav S, Wang Y . Metabolomics Signatures of Aging: Recent Advances. Aging Dis. 2021; 12(2):646-661. PMC: 7990359. DOI: 10.14336/AD.2020.0909. View

Morrison E, Champagne D, Dzieciatkowska M, Nemkov T, Zimring J, Hansen K . Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells. Nutrients. 2019; 11(6). PMC: 6627295. DOI: 10.3390/nu11061337. View

Fontana L, Cummings N, Arriola Apelo S, Neuman J, Kasza I, Schmidt B . Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health. Cell Rep. 2016; 16(2):520-530. PMC: 4947548. DOI: 10.1016/j.celrep.2016.05.092. View

Babygirija R, Lamming D . The regulation of healthspan and lifespan by dietary amino acids. Transl Med Aging. 2021; 5:17-30. PMC: 8277109. DOI: 10.1016/j.tma.2021.05.001. View

Mitchell S, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, Gonzalez-Reyes J . Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016; 23(6):1093-1112. PMC: 4911707. DOI: 10.1016/j.cmet.2016.05.027. View

Pavlova N, Thompson C . The Emerging Hallmarks of Cancer Metabolism. Cell Metab. 2016; 23(1):27-47. PMC: 4715268. DOI: 10.1016/j.cmet.2015.12.006. View

Karakelides H, Irving B, Short K, OBrien P, Nair K . Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function. Diabetes. 2009; 59(1):89-97. PMC: 2797949. DOI: 10.2337/db09-0591. View

10.

Schaum N, Lehallier B, Hahn O, Palovics R, Hosseinzadeh S, Lee S . Ageing hallmarks exhibit organ-specific temporal signatures. Nature. 2020; 583(7817):596-602. PMC: 7757734. DOI: 10.1038/s41586-020-2499-y. View

11.

Fujita S, Volpi E . Amino acids and muscle loss with aging. J Nutr. 2005; 136(1 Suppl):277S-80S. PMC: 3183816. DOI: 10.1093/jn/136.1.277S. View

12.

Uneyama H, Kobayashi H, Tonouchi N . New Functions and Potential Applications of Amino Acids. Adv Biochem Eng Biotechnol. 2016; 159:273-287. DOI: 10.1007/10_2016_35. View

13.

Horvath S, Raj K . DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018; 19(6):371-384. DOI: 10.1038/s41576-018-0004-3. View

14.

Scire A, Cianfruglia L, Minnelli C, Bartolini D, Torquato P, Principato G . Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways. Biofactors. 2018; 45(2):152-168. DOI: 10.1002/biof.1476. View

15.

Rupsingh R, Borrie M, Smith M, WELLS J, Bartha R . Reduced hippocampal glutamate in Alzheimer disease. Neurobiol Aging. 2009; 32(5):802-10. DOI: 10.1016/j.neurobiolaging.2009.05.002. View

16.

Gruning N, Rinnerthaler M, Bluemlein K, Mulleder M, Wamelink M, Lehrach H . Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells. Cell Metab. 2011; 14(3):415-27. PMC: 3202625. DOI: 10.1016/j.cmet.2011.06.017. View

17.

Cunnane S, Plourde M, Pifferi F, Begin M, Feart C, Barberger-Gateau P . Fish, docosahexaenoic acid and Alzheimer's disease. Prog Lipid Res. 2009; 48(5):239-56. DOI: 10.1016/j.plipres.2009.04.001. View

18.

Magkos F, Bradley D, Schweitzer G, Finck B, Eagon J, Ilkayeva O . Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. Diabetes. 2013; 62(8):2757-61. PMC: 3717831. DOI: 10.2337/db13-0185. View

19.

Gewirtz D . A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol. 1999; 57(7):727-41. DOI: 10.1016/s0006-2952(98)00307-4. View

20.

Kondoh H, Kameda M, Yanagida M . Whole Blood Metabolomics in Aging Research. Int J Mol Sci. 2020; 22(1). PMC: 7796096. DOI: 10.3390/ijms22010175. View