» Articles » PMID: 37396980

Heat and the Heart

Overview
Journal Yale J Biol Med
Specialty Biology
Date 2023 Jul 3
PMID 37396980
Authors
Affiliations
Soon will be listed here.
Abstract

Globally, more people die from cardiovascular disease than any other cause. Extreme heat can have serious implications for heart health, especially in people with pre-existing cardiovascular conditions. In this review, we examined the relationship between heat and the leading causes of cardiovascular diseases as well as the proposed physiological mechanisms for the deleterious effect of heat on the heart. The body's response to high temperatures, including dehydration, increased metabolic demand, hypercoagulability, electrolyte imbalances, and systemic inflammatory response, can place a significant strain on the heart. Epidemiological studies showed that heat can result in ischemic heart disease, stroke, heart failure, and arrhythmia. However, targeted research is needed to understand the underlying mechanisms of hot temperatures on these main causes of cardiovascular disease. Meanwhile, the absence of clinical guidance on how to manage heart diseases during heat events highlights the need for cardiologists and other health professionals to lead the charge in addressing the critical relationship between a warming climate and health.

Citing Articles

Liver fatty acid-binding protein point-of-care testing detects heat-induced organ damage: a pilot study in Japanese male self-defense force personnel.

Goto H, Ishikiriyama T, Oe K, Asaga R, Sato H, Mori K Sci Rep. 2025; 15(1):7197.

PMID: 40021940 PMC: 11871146. DOI: 10.1038/s41598-025-91685-7.


L-carnitine ameliorates myocardial injury by alleviating endoplasmic reticulum stress via inhibition of PERK pathway in exertional heatstroke rats.

Zhang B, He G, Wang Z, Zhou H, Huang X, Shen T Heliyon. 2024; 10(22):e40502.

PMID: 39641050 PMC: 11617224. DOI: 10.1016/j.heliyon.2024.e40502.


Impact of Extreme Heat on Cardiovascular Health in Kuwait: Present and Future Projections.

Alwadi Y, Al-Hemoud A, Khraishah H, Al-Mulla F, Koutrakis P, Ali H J Epidemiol Glob Health. 2024; 14(4):1711-1719.

PMID: 39621253 PMC: 11652549. DOI: 10.1007/s44197-024-00330-5.


SARS-CoV-2 and Environmental Changes: The Perfect Storm.

Caldarelli M, Rio P, Giambra V, Palucci I, Gasbarrini A, Gambassi G Curr Issues Mol Biol. 2024; 46(11):11835-11852.

PMID: 39590297 PMC: 11592541. DOI: 10.3390/cimb46110703.


A Review of the Links Between Work and Heart Disease in the 21st Century.

Makar A, Al-Hemoud A, Khraishah H, Berry J, Alahmad B Methodist Debakey Cardiovasc J. 2024; 20(5):71-80.

PMID: 39525380 PMC: 11546313. DOI: 10.14797/mdcvj.1478.


References
1.
Gasparrini A, Guo Y, Hashizume M, Lavigne E, Zanobetti A, Schwartz J . Mortality risk attributable to high and low ambient temperature: a multicountry observational study. Lancet. 2015; 386(9991):369-75. PMC: 4521077. DOI: 10.1016/S0140-6736(14)62114-0. View

2.
Moghadamnia M, Ardalan A, Mesdaghinia A, Keshtkar A, Naddafi K, Yekaninejad M . Ambient temperature and cardiovascular mortality: a systematic review and meta-analysis. PeerJ. 2017; 5:e3574. PMC: 5546177. DOI: 10.7717/peerj.3574. View

3.
McElroy S, Schwarz L, Green H, Corcos I, Guirguis K, Gershunov A . Defining heat waves and extreme heat events using sub-regional meteorological data to maximize benefits of early warning systems to population health. Sci Total Environ. 2020; 721:137678. DOI: 10.1016/j.scitotenv.2020.137678. View

4.
Cui J, Arbab-Zadeh A, Prasad A, Durand S, Levine B, Crandall C . Effects of heat stress on thermoregulatory responses in congestive heart failure patients. Circulation. 2005; 112(15):2286-92. DOI: 10.1161/CIRCULATIONAHA.105.540773. View

5.
Wang X, Lavigne E, Ouellette-Kuntz H, Chen B . Acute impacts of extreme temperature exposure on emergency room admissions related to mental and behavior disorders in Toronto, Canada. J Affect Disord. 2013; 155:154-61. DOI: 10.1016/j.jad.2013.10.042. View