Evaluation of Cadmium and Mercury on Cardiovascular and Neurological Systems: Effects on Humans and Fish

Overview

Journal Toxicol Rep

Date 2023 Jul 3

PMID 37396852

Authors

Azza Naija

Huseyin Cagatay Yalcin

Affiliations

Soon will be listed here.

Abstract

Chemicals are at the top of public health concerns and metals have received much attention in terms of toxicological studies. Cadmium (Cd) and mercury (Hg) are among the most toxic heavy metals and are widely distributed in the environment. They are considered important factors involved in several organ disturbances. Heart and brain tissues are not among the first exposure sites to Cd and Hg but they are directly affected and may manifest intoxication reactions leading to death. Many cases of human intoxication with Cd and Hg showed that these metals have potential cardiotoxic and neurotoxic effects. Human exposure to heavy metals is through fish consumption which is considered as an excellent source of human nutrients. In the current review, we will summarize the most known cases of human intoxication with Cd and Hg, highlight their toxic effects on fish, and investigate the common signal pathways of both Cd and Hg to affect heart and brain tissues. Also, we will present the most common biomarkers used in the assessment of cardiotoxicity and neurotoxicity using Zebrafish model.

Citing Articles

Peptide-Based Rapid and Selective Detection of Mercury in Aqueous Samples with Micro-Volume Glass Capillary Fluorometer.

Sosnowska M, Pitula E, Janik M, Bruzdziak P, Smietana M, Olszewski M Biosensors (Basel). 2024; 14(11).

PMID: 39589989 PMC: 11591704. DOI: 10.3390/bios14110530.

A Review on Pyridine Based Colorimetric and Fluorometric Chemosensor for Detection of Hg ion.

Alam M, Khan S J Fluoresc. 2024; .

PMID: 39527360 DOI: 10.1007/s10895-024-04005-z.

Mechanistic Evidence for Hg Removal from Wastewater by Biologically Produced Sulfur.

Jeong S, Park B, Yoon J, Kirkham M, Yang J, Kim H Toxics. 2024; 12(4).

PMID: 38668501 PMC: 11053473. DOI: 10.3390/toxics12040278.

Environmental Toxins and Alzheimer's Disease: a Comprehensive Analysis of Pathogenic Mechanisms and Therapeutic Modulation.

Dhapola R, Sharma P, Kumari S, Bhatti J, HariKrishnaReddy D Mol Neurobiol. 2023; 61(6):3657-3677.

PMID: 38006469 DOI: 10.1007/s12035-023-03805-x.

References

Xia Z, Dudek H, Miranti C, Greenberg M . Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J Neurosci. 1996; 16(17):5425-36. PMC: 6578897. View

Fagerberg B, Barregard L, Sallsten G, Forsgard N, Ostling G, Persson M . Cadmium exposure and atherosclerotic carotid plaques--results from the Malmö diet and Cancer study. Environ Res. 2014; 136:67-74. DOI: 10.1016/j.envres.2014.11.004. View

Ho N, Yang L, Legradi J, Armant O, Takamiya M, Rastegar S . Gene responses in the central nervous system of zebrafish embryos exposed to the neurotoxicant methyl mercury. Environ Sci Technol. 2013; 47(7):3316-25. DOI: 10.1021/es3050967. View

Satarug S, Nishijo M, Lasker J, Edwards R, Moore M . Kidney dysfunction and hypertension: role for cadmium, p450 and heme oxygenases?. Tohoku J Exp Med. 2006; 208(3):179-202. DOI: 10.1620/tjem.208.179. View

Oka T, Matsukura M, Okamoto M, Harada N, Kitano T, Miike T . Autonomic nervous functions in fetal type Minamata disease patients: assessment of heart rate variability. Tohoku J Exp Med. 2003; 198(4):215-21. DOI: 10.1620/tjem.198.215. View

Kysil E, Meshalkina D, Frick E, Echevarria D, Rosemberg D, Maximino C . Comparative Analyses of Zebrafish Anxiety-Like Behavior Using Conflict-Based Novelty Tests. Zebrafish. 2017; 14(3):197-208. DOI: 10.1089/zeb.2016.1415. View

Gesemann M, Maurer C, Neuhauss S . Excitatory amino acid transporters in the zebrafish: Letter to "Expression and functional analysis of Na(+)-dependent glutamate transporters from zebrafish brain" from Rico et al. Brain Res Bull. 2010; 83(5):202-6. DOI: 10.1016/j.brainresbull.2010.04.018. View

Guallar E, Vant Veer P, Bode P, Aro A, Gomez-Aracena J, Kark J . Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med. 2002; 347(22):1747-54. DOI: 10.1056/NEJMoa020157. View

Tellez-Plaza M, Gribble M, Saroja Voruganti V, Francesconi K, Goessler W, Umans J . Heritability and preliminary genome-wide linkage analysis of arsenic metabolites in urine. Environ Health Perspect. 2013; 121(3):345-51. PMC: 3621197. DOI: 10.1289/ehp.1205305. View

10.

Navas-Acien A, Selvin E, Sharrett A, Calderon-Aranda E, Silbergeld E, Guallar E . Lead, cadmium, smoking, and increased risk of peripheral arterial disease. Circulation. 2004; 109(25):3196-201. DOI: 10.1161/01.CIR.0000130848.18636.B2. View

11.

Solenkova N, Newman J, Berger J, Thurston G, Hochman J, Lamas G . Metal pollutants and cardiovascular disease: mechanisms and consequences of exposure. Am Heart J. 2014; 168(6):812-22. PMC: 4254412. DOI: 10.1016/j.ahj.2014.07.007. View

12.

Concha M, Russell C, Regan J, Tawk M, Sidi S, Gilmour D . Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality. Neuron. 2003; 39(3):423-38. DOI: 10.1016/s0896-6273(03)00437-9. View

13.

Traver D, Paw B, Poss K, Penberthy W, Lin S, Zon L . Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol. 2003; 4(12):1238-46. DOI: 10.1038/ni1007. View

14.

Jarup L, Berglund M, Elinder C, Nordberg G, Vahter M . Health effects of cadmium exposure--a review of the literature and a risk estimate. Scand J Work Environ Health. 1998; 24 Suppl 1:1-51. View

15.

Bristy M, Sarker K, Baki M, Quraishi S, Hossain M, Islam A . Health risk estimation of metals bioaccumulated in commercial fish from coastal areas and rivers in Bangladesh. Environ Toxicol Pharmacol. 2021; 86:103666. DOI: 10.1016/j.etap.2021.103666. View

16.

Dreosti E, Vendrell Llopis N, Carl M, Yaksi E, Wilson S . Left-right asymmetry is required for the habenulae to respond to both visual and olfactory stimuli. Curr Biol. 2014; 24(4):440-5. PMC: 3969106. DOI: 10.1016/j.cub.2014.01.016. View

17.

Kusch R, Krone P, Chivers D . Chronic exposure to low concentrations of waterborne cadmium during embryonic and larval development results in the long-term hindrance of antipredator behavior in zebrafish. Environ Toxicol Chem. 2007; 27(3):705-10. DOI: 10.1897/07-273.1. View

18.

Lai K, Gong Z, Tse W . Zebrafish as the toxicant screening model: Transgenic and omics approaches. Aquat Toxicol. 2021; 234:105813. DOI: 10.1016/j.aquatox.2021.105813. View

19.

Kuster E, Altenburger R . Comparison of cholin- and carboxylesterase enzyme inhibition and visible effects in the zebra fish embryo bioassay under short-term paraoxon-methyl exposure. Biomarkers. 2006; 11(4):341-54. DOI: 10.1080/13547500600742136. View

20.

Maciag M, Wnorowski A, Mierzejewska M, Plazinska A . Pharmacological assessment of zebrafish-based cardiotoxicity models. Biomed Pharmacother. 2022; 148:112695. DOI: 10.1016/j.biopha.2022.112695. View