The EANM Guideline on Radioiodine Therapy of Benign Thyroid Disease

Overview

Journal Eur J Nucl Med Mol Imaging

Specialties Biophysics
Nuclear Medicine
Radiology

Date 2023 Jul 3

PMID 37395802

Authors

Alfredo Campenni

Anca M Avram

Frederik A Verburg

Ioannis Iakovou

Heribert Hanscheid

Bart de Keizer

Petra Petranovic Ovcaricek

Luca Giovanella

Affiliations

Soon will be listed here.

Abstract

This document provides the new EANM guideline on radioiodine therapy of benign thyroid disease. Its aim is to guide nuclear medicine physicians, endocrinologists, and practitioners in the selection of patients for radioiodine therapy. Its recommendations on patients' preparation, empiric and dosimetric therapeutic approaches, applied radioiodine activity, radiation protection requirements, and patients follow-up after administration of radioiodine therapy are extensively discussed.

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References

Willegaignon J, Sapienza M, Buchpiguel C . Radioiodine therapy for Graves disease: thyroid absorbed dose of 300 Gy-tuning the target for therapy planning. Clin Nucl Med. 2013; 38(4):231-6. DOI: 10.1097/RLU.0b013e3182816717. View

Albino C, Mesa Jr C, Olandoski M, Ueda C, Woellner L, Goedert C . Recombinant human thyrotropin as adjuvant in the treatment of multinodular goiters with radioiodine. J Clin Endocrinol Metab. 2005; 90(5):2775-80. DOI: 10.1210/jc.2004-0458. View

Giuffrida G, Giovinazzo S, Certo R, Vicchio T, Baldari S, Campenni A . An uncommon case of Marine-Lenhart syndrome. Arq Bras Endocrinol Metabol. 2014; 58(4):398-401. DOI: 10.1590/0004-2730000003173. View

Cooper D . Hyperthyroidism. Lancet. 2003; 362(9382):459-68. DOI: 10.1016/S0140-6736(03)14073-1. View

Mishra A, Agarwal A, Agarwal G, Mishra S . Total thyroidectomy for benign thyroid disorders in an endemic region. World J Surg. 2001; 25(3):307-10. DOI: 10.1007/s002680020100. View

Diehl L, Garcia V, Bonnema S, Hegedus L, Albino C, Graf H . Management of the nontoxic multinodular goiter in Latin America: comparison with North America and Europe, an electronic survey. J Clin Endocrinol Metab. 2004; 90(1):117-23. DOI: 10.1210/jc.2004-1722. View

Bartalena L, Marcocci C, Tanda M, Manetti L, DellUnto E, Bartolomei M . Cigarette smoking and treatment outcomes in Graves ophthalmopathy. Ann Intern Med. 1998; 129(8):632-5. DOI: 10.7326/0003-4819-129-8-199810150-00010. View

Pena S, Arum S, Cross M, Magnani B, Pearce E, Oates M . 123I thyroid uptake and thyroid size at 24, 48, and 72 hours after the administration of recombinant human thyroid-stimulating hormone to normal volunteers. J Clin Endocrinol Metab. 2005; 91(2):506-10. DOI: 10.1210/jc.2005-1986. View

Klein I, Danzi S . Thyroid disease and the heart. Circulation. 2007; 116(15):1725-35. DOI: 10.1161/CIRCULATIONAHA.106.678326. View

10.

Lau L, Ghaznavi S, Frolkis A, Stephenson A, Robertson H, Rabi D . Malignancy risk of hyperfunctioning thyroid nodules compared with non-toxic nodules: systematic review and a meta-analysis. Thyroid Res. 2021; 14(1):3. PMC: 7905613. DOI: 10.1186/s13044-021-00094-1. View

11.

Toft A . Clinical practice. Subclinical hyperthyroidism. N Engl J Med. 2001; 345(7):512-6. DOI: 10.1056/NEJMcp010145. View

12.

Stan M, Bahn R . Risk factors for development or deterioration of Graves' ophthalmopathy. Thyroid. 2010; 20(7):777-83. PMC: 3357079. DOI: 10.1089/thy.2010.1634. View

13.

Paz-Filho G, Mesa-Junior C, Olandoski M, Woellner L, Goedert C, Boguszewski C . Effect of 30 mCi radioiodine on multinodular goiter previously treated with recombinant human thyroid-stimulating hormone. Braz J Med Biol Res. 2007; 40(12):1661-70. DOI: 10.1590/s0100-879x2006005000186. View

14.

Hegedus L, Hansen B, Knudsen N, Hansen J . Reduction of size of thyroid with radioactive iodine in multinodular non-toxic goitre. BMJ. 1988; 297(6649):661-2. PMC: 1834361. DOI: 10.1136/bmj.297.6649.661. View

15.

Reinhardt M, Joe A, von Mallek D, Zimmerlin M, Manka-Waluch A, Palmedo H . Dose selection for radioiodine therapy of borderline hyperthyroid patients with multifocal and disseminated autonomy on the basis of 99mTc-pertechnetate thyroid uptake. Eur J Nucl Med Mol Imaging. 2002; 29(4):480-5. DOI: 10.1007/s00259-001-0722-0. View

16.

Ruggeri R, Campenni A, Sindoni A, Baldari S, Trimarchi F, Benvenga S . Association of autonomously functioning thyroid nodules with Hashimoto's thyroiditis: study on a large series of patients. Exp Clin Endocrinol Diabetes. 2011; 119(10):621-7. DOI: 10.1055/s-0031-1279705. View

17.

Kobe C, Eschner W, Wild M, Rahlff I, Sudbrock F, Schmidt M . Radioiodine therapy of benign thyroid disorders: what are the effective thyroidal half-life and uptake of 131I?. Nucl Med Commun. 2009; 31(3):201-5. DOI: 10.1097/MNM.0b013e328333d303. View

18.

Hegedus L . Clinical practice. The thyroid nodule. N Engl J Med. 2004; 351(17):1764-71. DOI: 10.1056/NEJMcp031436. View

19.

Bonnema S, Bennedbaek F, Veje A, Marving J, Hegedus L . Propylthiouracil before 131I therapy of hyperthyroid diseases: effect on cure rate evaluated by a randomized clinical trial. J Clin Endocrinol Metab. 2004; 89(9):4439-44. DOI: 10.1210/jc.2004-0247. View

20.

Reinhardt M, Brink I, Joe A, von Mallek D, Ezziddin S, Palmedo H . Radioiodine therapy in Graves' disease based on tissue-absorbed dose calculations: effect of pre-treatment thyroid volume on clinical outcome. Eur J Nucl Med Mol Imaging. 2002; 29(9):1118-24. DOI: 10.1007/s00259-002-0877-3. View