The Role of Macrophages in the Lymphoproliferative Response to Mycobacterium Leprae in Vitro

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1978 Oct 1

PMID 373933

Citations 14

Authors

H Hirschberg

Affiliations

Soon will be listed here.

Abstract

Peripheral blood lymphocytes from patients suffering from lepromatous leprosy do not normally react in vitro to stimulation by Mycobacterium leprae antigens. In contrast, we found that T cells from non-responding patients in combination with macrophages from responding patients or healthy contacts did respond well to M. leprae. Conversely, T cells from responding patients or healthy contacts in combinations with macrophages from non-responding patients failed to respond. It seems, therefore, that the lack of response normally observed in in vitro tests using cells from lepromatous leprosy patients is due to a failure of their macrophages to present M. leprae antigens in an immunogenic form.

Citing Articles

Failure to induce delayed-type hypersensitivity to Mycobacterium leprae in long-term treated lepromatous leprosy patients.

Smelt A, Rees R, Liew F Clin Exp Immunol. 1981; 44(3):507-11.

PMID: 7035031 PMC: 1537307.

The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy.

Nath I, Singh R Clin Exp Immunol. 1980; 41(3):406-14.

PMID: 7002396 PMC: 1537043.

Monocyte-derived soluble suppressor factor(s) in patients with lepromatous leprosy.

Sathish M, Bhutani L, Sharma A, Nath I Infect Immun. 1983; 42(3):890-9.

PMID: 6605932 PMC: 264383. DOI: 10.1128/iai.42.3.890-899.1983.

Natural suppressor cells in human leprosy: the role of HLA-D-identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses.

Nath I, van Rood J, Mehra N, Vaidya M Clin Exp Immunol. 1980; 42(2):203-10.

PMID: 6451335 PMC: 1537096.

Alterations in the membrane of macrophages from leprosy patients.

Birdi T, Mistry N, Mahadevan P, Antia N Infect Immun. 1983; 41(1):121-7.

PMID: 6345387 PMC: 264751. DOI: 10.1128/iai.41.1.121-127.1983.

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