O-GlcNAcylation: A Crucial Regulator in Cancer-Associated Biological Events

Overview

Journal Cell Biochem Biophys

Specialties Biochemistry
Biophysics
Cell Biology

Date 2023 Jul 1

PMID 37392316

Authors

Zhihong Ran

Lei Zhang

Ming Dong

Yu Zhang

Lulu Chen

Qibin Song

Affiliations

Soon will be listed here.

Abstract

O-GlcNAcylation, a recently discovered post-translational modification of proteins, plays a crucial role in regulating protein structure and function, and is closely associated with multiple diseases. Research has shown that O-GlcNAcylation is abnormally upregulated in most cancers, promoting disease progression. To elucidate the roles of O-GlcNAcylation in cancer, this review summarizes various cancer-associated biological events regulated by O-GlcNAcylation and the corresponding signaling pathways. This work may provide insights for future studies on the function or underlying mechanisms of O-GlcNAcylation in cancer.

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