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Acute Acrylamide Poisoning with Severe Symptoms in a Short Time: a Case Report

Overview
Journal Int J Emerg Med
Publisher Biomed Central
Specialty Emergency Medicine
Date 2023 Jun 29
PMID 37386375
Authors
Rie Yamamoto
Takayuki Yasuoka
Junya Matsushima
Youhei Tsubouchi
Hideaki Kanazashi
Keiji Sakurai
Tomoki Hanazawa
Yoshito Kamijo
Kazuki Akieda
Affiliations
Soon will be listed here.
Abstract

Background: Acrylamide poisoning is often reported as chronic poisoning presenting with peripheral neuropathy or carcinogenic action due to long-term exposure to low concentrations. However, there have been few reports of acute poisoning due to oral ingestion of acrylamide, where the symptoms appear a few hours after ingestion. Here, we report a case of acute acrylamide poisoning where a high concentration was ingested in a short time, resulting in a fatal outcome due to the rapid course of events.

Case Presentation: The patient was an adolescent female who ingested 150 ml (148 g) of acrylamide with suicidal intent. A disorder of consciousness was observed when the emergency medical team arrived 36 min later. An hour later, tracheal intubation and intravenous access were performed at a hospital, and 2 h after that, she was transported to our hospital. After she arrived at the hospital, circulatory dynamics could not be maintained despite vasopressor and colloid osmotic infusion, and hemodialysis could not be introduced. Subsequently, cardiopulmonary arrest occurred, and the patient passed away 7 h after ingestion. In the present case, severe symptoms appeared shortly after acrylamide ingestion, unlike other reported cases. In previous report summarizing animal studies, there was a relationship among the symptoms of acute poisoning, the dose, and onset time. The data from this case were compared to those from previous reports, and we were able to predict the early appearance of severe symptoms based on this comparison.

Conclusion: The severity of acute acrylamide poisoning by oral ingestion was primarily dependent on the amount and rate of ingestion.

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