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Effects of High-flow Nasal Cannula Oxygen Therapy for Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Combination with Type II Respiratory Failure

Overview
Journal J Int Med Res
Publisher Sage Publications
Specialty General Medicine
Date 2023 Jun 28
PMID 37377101
Authors
Aiming Liu
Yaqing Zhou
Zunguo Pu
Affiliations
Soon will be listed here.
Abstract

Objective: To evaluate the therapeutic effects of high-flow nasal cannula (HFNC) oxygen therapy in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and type II respiratory failure.

Methods: Seventy-two patients with AECOPD and type II respiratory failure were randomly allocated to an HFNC oxygen therapy trial group or a non-invasive positive-pressure ventilator therapy (NIPPV) control group. Their arterial blood gas parameters and comfort, evaluated using a questionnaire, were compared before and after the therapeutic interventions.

Results: The PaCO and blood concentration of both groups were significantly reduced by the treatments, whereas the pH, PaO and PaO/FiO were increased. The PaCO of the experimental group was significantly lower than that of the control group following treatment. The PaO of the experimental group was significantly higher than that of the control group. The tracheal intubation rates of the two groups did not significantly differ. After treatment, all the indices of comfort were rated higher in the HFNC group than in the NIPPV group.

Conclusions: HFNC has a good therapeutic effect in patients with AECOPD and type II respiratory failure. It improves patient comfort and has clinical value.

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