Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 Jun 28

PMID 37376641

Authors

Mihayl Varbanov

Stephanie Philippot

Miguel A Gonzalez-Cardenete

Affiliations

Soon will be listed here.

Abstract

The abietane diterpene (+)-ferruginol (), like other natural and semisynthetic abietanes, is distinguished for its interesting pharmacological properties such as antimicrobial activity, including antiviral. In this study, selected C18-functionalized semisynthetic abietanes prepared from the commercially available (+)-dehydroabietylamine or methyl dehydroabietate were tested in vitro against human coronavirus 229E (HCoV-229E). As a result, a new ferruginol analogue caused a relevant reduction in virus titer as well as the inhibition of a cytopathic effect. A toxicity prediction based on in silico analysis was also performed as well as an estimation of bioavailability. This work demonstrates the antimicrobial and specifically antiviral activity of two tested compounds, making these molecules interesting for the development of new antivirals.

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