Functionalized and Nonfunctionalized Nanosystems for Mitochondrial Drug Delivery with Metallic Nanoparticles

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Jun 28

PMID 37375256

Authors

Shashi Kiran Misra

Jessica M Rosenholm

Kamla Pathak

Affiliations

Soon will be listed here.

Abstract

The application of metallic nanoparticles as a novel therapeutic tool has significant potential to facilitate the treatment and diagnosis of mitochondria-based disorders. Recently, subcellular mitochondria have been trialed to cure pathologies that depend on their dysfunction. Nanoparticles made from metals and their oxides (including gold, iron, silver, platinum, zinc oxide, and titanium dioxide) have unique modi operandi that can competently rectify mitochondrial disorders. This review presents insight into the recent research reports on exposure to a myriad of metallic nanoparticles that can alter the dynamic ultrastructure of mitochondria (via altering metabolic homeostasis), as well as pause ATP production, and trigger oxidative stress. The facts and figures have been compiled from more than a hundred PubMed, Web of Science, and Scopus indexed articles that describe the essential functions of mitochondria for the management of human diseases. Nanoengineered metals and their oxide nanoparticles are targeted at the mitochondrial architecture that partakes in the management of a myriad of health issues, including different cancers. These nanosystems not only act as antioxidants but are also fabricated for the delivery of chemotherapeutic agents. However, the biocompatibility, safety, and efficacy of using metal nanoparticles is contested among researchers, which will be discussed further in this review.

References

Skalska J, Dabrowska-Bouta B, Frontczak-Baniewicz M, Sulkowski G, Struzynska L . A Low Dose of Nanoparticulate Silver Induces Mitochondrial Dysfunction and Autophagy in Adult Rat Brain. Neurotox Res. 2020; 38(3):650-664. PMC: 7467969. DOI: 10.1007/s12640-020-00239-4. View

Baky N, Faddah L, Al-Rasheed N, Fatani A . Induction of inflammation, DNA damage and apoptosis in rat heart after oral exposure to zinc oxide nanoparticles and the cardioprotective role of α-lipoic acid and vitamin E. Drug Res (Stuttg). 2013; 63(5):228-36. DOI: 10.1055/s-0033-1334923. View

Sharma V, Anderson D, Dhawan A . Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2). Apoptosis. 2012; 17(8):852-70. DOI: 10.1007/s10495-012-0705-6. View

Maltseva V, Gudkov S, Turovsky E . Modulation of the Functional State of Mouse Neutrophils by Selenium Nanoparticles In Vivo. Int J Mol Sci. 2022; 23(21). PMC: 9655531. DOI: 10.3390/ijms232113651. View

Brassolatti P, de Almeida Rodolpho J, de Godoy K, de Castro C, Luna G, de Lima Fragelli B . Functionalized Titanium Nanoparticles Induce Oxidative Stress and Cell Death in Human Skin Cells. Int J Nanomedicine. 2022; 17:1495-1509. PMC: 8978907. DOI: 10.2147/IJN.S325767. View

Sadhukhan P, Kundu M, Chatterjee S, Ghosh N, Manna P, Das J . Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy. Mater Sci Eng C Mater Biol Appl. 2019; 100:129-140. DOI: 10.1016/j.msec.2019.02.096. View

Yue D, Zeng C, Okyere S, Chen Z, Hu Y . Glycine nano-selenium prevents brain oxidative stress and neurobehavioral abnormalities caused by MPTP in rats. J Trace Elem Med Biol. 2020; 64:126680. DOI: 10.1016/j.jtemb.2020.126680. View

Kuhlbrandt W . Structure and function of mitochondrial membrane protein complexes. BMC Biol. 2015; 13:89. PMC: 4625866. DOI: 10.1186/s12915-015-0201-x. View

Ren Z, Han X, Wang L, Wang Y . Hyaluronic acid functionalized ZnO nanoparticles co-deliver AS and GOD for synergistic cancer starvation and oxidative damage. Sci Rep. 2022; 12(1):4574. PMC: 8931118. DOI: 10.1038/s41598-022-08627-w. View

10.

Gopisetty M, Kovacs D, Igaz N, Ronavari A, Belteky P, Razga Z . Endoplasmic reticulum stress: major player in size-dependent inhibition of P-glycoprotein by silver nanoparticles in multidrug-resistant breast cancer cells. J Nanobiotechnology. 2019; 17(1):9. PMC: 6341731. DOI: 10.1186/s12951-019-0448-4. View

11.

Johnson S, Yanos M, Kayser E, Quintana A, Sangesland M, Castanza A . mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science. 2013; 342(6165):1524-8. PMC: 4055856. DOI: 10.1126/science.1244360. View

12.

Chen Q, Wang N, Zhu M, Lu J, Zhong H, Xue X . TiO nanoparticles cause mitochondrial dysfunction, activate inflammatory responses, and attenuate phagocytosis in macrophages: A proteomic and metabolomic insight. Redox Biol. 2018; 15:266-276. PMC: 5752088. DOI: 10.1016/j.redox.2017.12.011. View

13.

Piao M, Kang K, Lee I, Kim H, Kim S, Choi J . Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis. Toxicol Lett. 2010; 201(1):92-100. DOI: 10.1016/j.toxlet.2010.12.010. View

14.

Choi Y, Cho T, Kim J, Han S, Kim S . Amine terminated G-6 PAMAM dendrimer and its interaction with DNA probed by Hoechst 33258. Biophys Chem. 2006; 121(2):142-9. DOI: 10.1016/j.bpc.2006.01.005. View

15.

Yu H, Koilkonda R, Chou T, Porciatti V, Ozdemir S, Chiodo V . Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model. Proc Natl Acad Sci U S A. 2012; 109(20):E1238-47. PMC: 3356643. DOI: 10.1073/pnas.1119577109. View

16.

Nadanaciva S, Dykens J, Bernal A, Capaldi R, Will Y . Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration. Toxicol Appl Pharmacol. 2007; 223(3):277-87. DOI: 10.1016/j.taap.2007.06.003. View

17.

Hauser A, Mitov M, Daley E, McGarry R, Anderson K, Hilt J . Targeted iron oxide nanoparticles for the enhancement of radiation therapy. Biomaterials. 2016; 105:127-135. PMC: 5321199. DOI: 10.1016/j.biomaterials.2016.07.032. View

18.

Marrache S, Pathak R, Darley K, Choi J, Zaver D, Kolishetti N . Nanocarriers for tracking and treating diseases. Curr Med Chem. 2013; 20(28):3500-14. PMC: 8085808. DOI: 10.2174/0929867311320280007. View

19.

Bartsakoulia M, Myller J, Gomez-Duran A, Yu-Wai-Man P, Boczonadi V, Horvath R . Cysteine Supplementation May be Beneficial in a Subgroup of Mitochondrial Translation Deficiencies. J Neuromuscul Dis. 2016; 3(3):363-379. DOI: 10.3233/JND-160178. View

20.

Sharma A, Liaw K, Sharma R, Zhang Z, Kannan S, Kannan R . Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics. Theranostics. 2018; 8(20):5529-5547. PMC: 6276292. DOI: 10.7150/thno.29039. View