Endothelial Cells and Mitochondria: Two Key Players in Liver Transplantation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jun 28

PMID 37373238

Authors

Alessandro Parente

Mauricio Flores Carvalho

Andrea Schlegel

Affiliations

Soon will be listed here.

Abstract

Building the inner layer of our blood vessels, the endothelium forms an important line communicating with deeper parenchymal cells in our organs. Previously considered passive, endothelial cells are increasingly recognized as key players in intercellular crosstalk, vascular homeostasis, and blood fluidity. Comparable to other cells, their metabolic function strongly depends on mitochondrial health, and the response to flow changes observed in endothelial cells is linked to their mitochondrial metabolism. Despite the direct impact of new dynamic preservation concepts in organ transplantation, the impact of different perfusion conditions on sinusoidal endothelial cells is not yet explored well enough. This article therefore describes the key role of liver sinusoidal endothelial cells (LSECs) together with their mitochondrial function in the context of liver transplantation. The currently available ex situ machine perfusion strategies are described with their effect on LSEC health. Specific perfusion conditions, including perfusion pressure, duration, and perfusate oxygenation are critically discussed considering the metabolic function and integrity of liver endothelial cells and their mitochondria.

Citing Articles

Machine Perfusion as a Strategy to Decrease Ischemia-Reperfusion Injury and Lower Cancer Recurrence Following Liver Transplantation.

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PMID: 39682147 PMC: 11639801. DOI: 10.3390/cancers16233959.

Dual hypothermic oxygenated machine perfusion of the liver reduces post-transplant biliary complications: a retrospective cohort study.

Pereyra D, Dingfelder J, Riha M, Kacar S, Rauter L, Becker N Int J Surg. 2024; 110(12):7909-7918.

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The Impact of Biliary Injury on the Recurrence of Biliary Cancer and Benign Disease after Liver Transplantation: Risk Factors and Mechanisms.

Wehrle C, Panconesi R, Satish S, Maspero M, Jiao C, Sun K Cancers (Basel). 2024; 16(16).

PMID: 39199562 PMC: 11352383. DOI: 10.3390/cancers16162789.

Focusing on Ischemic Reperfusion Injury in the New Era of Dynamic Machine Perfusion in Liver Transplantation.

Chullo G, Panisello-Rosello A, Marquez N, Colmenero J, Brunet M, Pera M Int J Mol Sci. 2024; 25(2).

PMID: 38256190 PMC: 10816079. DOI: 10.3390/ijms25021117.

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