Axis and Differential Expression May Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm

The aim of this study was to evaluate the expression of , , , and genes in Myelodysplastic neoplasm (MDS) to identify possible targets of ubiquitination and deubiquitination in MDS pathobiology. To achieve this, eight datasets from the Gene Expression Omnibus (GEO) database were integrated, and the expression relationship of these genes was analyzed in 1092 MDS patients and healthy controls. Our results showed that , , and were upregulated in MDS patients compared with healthy individuals, but only in mononucleated cells collected from bone marrow samples ( < 0.001). In contrast, only the gene showed a downregulated expression compared with healthy individuals ( = 0.03). Additionally, the upregulation of expression was identified in MDS patients with chromosomal abnormalities compared with patients with normal karyotypes ( = 0.0321), and the downregulation of expression was associated with MDS hypoplastic patients ( = 0.033). Finally, the and genes were strongly correlated with MDS (r = 0.82; r2 = 0.67; < 0.0001). These findings suggest that the differential expression of the axis and may play an important role in controlling genomic instability and the chromosomal abnormalities that are a striking characteristic of MDS.