Structural Insight into How WDR4 Promotes the TRNA N7-methylguanosine Methyltransferase Activity of METTL1
Overview
Affiliations
Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases.
Zhou W, Yi Y, Cao W, Zhong X, Chen L Front Pharmacol. 2025; 15():1491763.
PMID: 39850560 PMC: 11754259. DOI: 10.3389/fphar.2024.1491763.
Ma J, Zheng S, An C, Han H, Li Q, Huang Y Proc Natl Acad Sci U S A. 2024; 121(45):e2405886121.
PMID: 39471230 PMC: 11551429. DOI: 10.1073/pnas.2405886121.
Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage.
Burkhalter M, Stiff T, Maerz L, Casar Tena T, Wiese H, Gerhards J Cell Death Dis. 2024; 15(9):660.
PMID: 39251572 PMC: 11384789. DOI: 10.1038/s41419-024-07042-5.
Writers, readers, and erasers RNA modifications and drug resistance in cancer.
Chen D, Gu X, Nurzat Y, Xu L, Li X, Wu L Mol Cancer. 2024; 23(1):178.
PMID: 39215288 PMC: 11363509. DOI: 10.1186/s12943-024-02089-6.
[Research progress on monogenic inherited glomerular diseases with central nervous system symptoms].
Wang Y, He Q Zhongguo Dang Dai Er Ke Za Zhi. 2024; 26(6):652-658.
PMID: 38926384 PMC: 11562061. DOI: 10.7499/j.issn.1008-8830.2312054.