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Structural Insight into How WDR4 Promotes the TRNA N7-methylguanosine Methyltransferase Activity of METTL1

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Journal Cell Discov
Date 2023 Jun 27
PMID 37369656
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References
1.
Trimouille A, Lasseaux E, Barat P, Deiller C, Drunat S, Rooryck C . Further delineation of the phenotype caused by biallelic variants in the WDR4 gene. Clin Genet. 2017; 93(2):374-377. DOI: 10.1111/cge.13074. View

2.
Han H, Yang C, Ma J, Zhang S, Zheng S, Ling R . N-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis. Nat Commun. 2022; 13(1):1478. PMC: 8933395. DOI: 10.1038/s41467-022-29125-7. View

3.
Ma J, Han H, Huang Y, Yang C, Zheng S, Cai T . METTL1/WDR4-mediated mG tRNA modifications and mG codon usage promote mRNA translation and lung cancer progression. Mol Ther. 2021; 29(12):3422-3435. PMC: 8636169. DOI: 10.1016/j.ymthe.2021.08.005. View

4.
Lin S, Liu Q, Lelyveld V, Choe J, Szostak J, Gregory R . Mettl1/Wdr4-Mediated mG tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. Mol Cell. 2018; 71(2):244-255.e5. PMC: 6086580. DOI: 10.1016/j.molcel.2018.06.001. View

5.
Tomikawa C . 7-Methylguanosine Modifications in Transfer RNA (tRNA). Int J Mol Sci. 2018; 19(12). PMC: 6320965. DOI: 10.3390/ijms19124080. View