Splenic Rupture Secondary to Amyloidosis: A Case Report and Review of the Literature

Overview

Journal Hematol Rep

Publisher MDPI

Date 2023 Jun 27

PMID 37367087

Authors

Hisham F Bahmad

Samantha Gogola

Lorena Burton

Ferial Alloush

Mike Cusnir

Michael Schwartz

Lydia Howard

Vathany Sriganeshan

Affiliations

Soon will be listed here.

Abstract

Amyloidosis is a term describing the extracellular deposit of fibrils composed of subunits of several different normal serum proteins in various tissues. Amyloid light chain (AL) amyloidosis contains fibrils that are composed of fragments of monoclonal light chains. Many different disorders and conditions can lead to spontaneous splenic rupture, including AL amyloidosis. We present a case of a 64-year-old woman with spontaneous splenic rupture and hemorrhage. A final diagnosis of systemic amyloidosis secondary to plasma cell myeloma was made with infiltrative cardiomyopathy and possible diastolic congestive heart failure exacerbation. We also provide a narrative review of all documented cases of splenic rupture associated with amyloidosis from the year 2000 until January 2023, along with the main clinical findings and management strategies.

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