Phytoglycogen to Enhance the Solubility and Permeation of Resveratrol

Overview

Journal Food Biophys

Specialty Biophysics

Date 2023 Jun 26

PMID 37362010

Authors

Jingfan Chen

Yuan Yao

Affiliations

Soon will be listed here.

Abstract

This study investigated the capability of phytoglycogen (PG) to improve the water-soluble amount and bioavailability of resveratrol (RES). RES and PG were incorporated through co-solvent mixing and spray-drying to form PG-RES solid dispersions. The soluble amount of RES of PG-RES solid dispersions reached 289.6 μg/mL at PG:RES ratio of 50:1, compared with 45.6 μg/mL for RES alone. X-ray powder diffraction and Fourier-transform infrared spectroscopy tests suggested a significant reduction of RES crystallinity in PG-RES solid dispersions and the formation of hydrogen bonds between RES and PG. Caco-2 monolayer permeation tests showed that, at low RES loading concentrations (15 and 30 μg/mL), PG-RES solid dispersions achieved greater permeation of RES (0.60 and 1.32 μg/well, respectively) than RES alone (0.32 and 0.90 μg/well, respectively). At an RES loading of 150 μg/mL, PG-RES solid dispersion realized RES permeation of 5.89 μg/well, suggesting the potential of PG in enhancing the bioavailability of RES.

Citing Articles

Effects of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review.

Zamanian M, Shahbazi T, Kazmi S, Hussien B, Sharma A, Qasim M Food Sci Nutr. 2024; 12(11):8825-8845.

PMID: 39620024 PMC: 11606877. DOI: 10.1002/fsn3.4555.

References

Wegiel L, Mauer L, Edgar K, Taylor L . Crystallization of amorphous solid dispersions of resveratrol during preparation and storage-Impact of different polymers. J Pharm Sci. 2012; 102(1):171-84. DOI: 10.1002/jps.23358. View

Ter Ellen B, Dinesh Kumar N, Bouma E, Troost B, van de Pol D, van der Ende-Metselaar H . Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air-Liquid Interface Cultured Human Primary Bronchial Epithelial Cells. Viruses. 2021; 13(7). PMC: 8309965. DOI: 10.3390/v13071335. View

Sessa M, Balestrieri M, Ferrari G, Servillo L, Castaldo D, DOnofrio N . Bioavailability of encapsulated resveratrol into nanoemulsion-based delivery systems. Food Chem. 2013; 147:42-50. DOI: 10.1016/j.foodchem.2013.09.088. View

Porte C, Voduc N, Zhang G, Seguin I, Tardiff D, Singhal N . Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Clin Pharmacokinet. 2010; 49(7):449-54. DOI: 10.2165/11531820-000000000-00000. View

Koga C, Andrade J, Ferruzzi M, Lee Y . Stability of Trans-Resveratrol Encapsulated in a Protein Matrix Produced Using Spray Drying to UV Light Stress and Simulated Gastro-Intestinal Digestion. J Food Sci. 2015; 81(2):C292-300. DOI: 10.1111/1750-3841.13176. View

Cheng C, Luo J, Lau C, Chen Z, Tian X, Huang Y . Pharmacological basis and new insights of resveratrol action in the cardiovascular system. Br J Pharmacol. 2019; 177(6):1258-1277. PMC: 7056472. DOI: 10.1111/bph.14801. View

Chen S, Han Y, Jian L, Liao W, Zhang Y, Gao Y . Fabrication, characterization, physicochemical stability of zein-chitosan nanocomplex for co-encapsulating curcumin and resveratrol. Carbohydr Polym. 2020; 236:116090. DOI: 10.1016/j.carbpol.2020.116090. View

Chen H, Yao Y . Phytoglycogen improves the water solubility and Caco-2 monolayer permeation of quercetin. Food Chem. 2016; 221:248-257. DOI: 10.1016/j.foodchem.2016.10.064. View

Tang H, Xiang S, Li X, Zhou J, Kuang C . Preparation and in vitro performance evaluation of resveratrol for oral self-microemulsion. PLoS One. 2019; 14(4):e0214544. PMC: 6467382. DOI: 10.1371/journal.pone.0214544. View

10.

Xie Y, Yao Y . Octenylsuccinate hydroxypropyl phytoglycogen, a dendrimer-like biopolymer, solubilizes poorly water-soluble active pharmaceutical ingredients. Carbohydr Polym. 2017; 180:29-37. DOI: 10.1016/j.carbpol.2017.10.004. View

11.

Anjos O, Campos M, Ruiz P, Antunes P . Application of FTIR-ATR spectroscopy to the quantification of sugar in honey. Food Chem. 2014; 169:218-23. DOI: 10.1016/j.foodchem.2014.07.138. View

12.

Chen H, Yao Y . Phytoglycogen to increase lutein solubility and its permeation through Caco-2 monolayer. Food Res Int. 2017; 97:258-264. DOI: 10.1016/j.foodres.2017.04.021. View

13.

Gumireddy A, Christman R, Kumari D, Tiwari A, North E, Chauhan H . Preparation, Characterization, and In vitro Evaluation of Curcumin- and Resveratrol-Loaded Solid Lipid Nanoparticles. AAPS PharmSciTech. 2019; 20(4):145. DOI: 10.1208/s12249-019-1349-4. View

14.

Neves A, Martins S, Segundo M, Reis S . Nanoscale Delivery of Resveratrol towards Enhancement of Supplements and Nutraceuticals. Nutrients. 2016; 8(3):131. PMC: 4808861. DOI: 10.3390/nu8030131. View

15.

Juere E, Florek J, Bouchoucha M, Jambhrunkar S, Wong K, Popat A . In Vitro Dissolution, Cellular Membrane Permeability, and Anti-Inflammatory Response of Resveratrol-Encapsulated Mesoporous Silica Nanoparticles. Mol Pharm. 2017; 14(12):4431-4441. DOI: 10.1021/acs.molpharmaceut.7b00529. View

16.

Das D, Maulik N . Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Mol Interv. 2006; 6(1):36-47. DOI: 10.1124/mi.6.1.7. View

17.

Murcia M, Martinez-Tome M . Antioxidant activity of resveratrol compared with common food additives. J Food Prot. 2001; 64(3):379-84. DOI: 10.4315/0362-028x-64.3.379. View

18.

Gadalla H, Soliman G, Mohammed F, El-Sayed A . Development and in vitro/in vivo evaluation of Zn-pectinate microparticles reinforced with chitosan for the colonic delivery of progesterone. Drug Deliv. 2015; 23(7):2541-2554. DOI: 10.3109/10717544.2015.1028602. View

19.

Huang M, Liang C, Tan C, Huang S, Ying R, Wang Y . Liposome co-encapsulation as a strategy for the delivery of curcumin and resveratrol. Food Funct. 2019; 10(10):6447-6458. DOI: 10.1039/c9fo01338e. View

20.

Herneisey M, Williams J, Mirtic J, Liu L, Potdar S, Bagia C . Development and characterization of resveratrol nanoemulsions carrying dual-imaging agents. Ther Deliv. 2016; 7(12):795-808. PMC: 5239992. DOI: 10.4155/tde-2016-0050. View