An Uncommon Case of Isolated Elevation of Aspartate Aminotransferase in a Young Male

Overview

Journal Intern Emerg Med

Publisher Springer

Specialties Emergency Medicine
General Medicine

Date 2023 Jun 26

PMID 37358779

Authors

Caie Wang

Ran Wang

Xiao Tian

Baocheng Deng

Zhenjiao Gao

Wenwen Zhang

Xuantong Liu

Yunhui Li

Xingshun Qi

Affiliations

Soon will be listed here.

References

Mandato C, Vajro P . Isolated aspartate aminotransferase elevation: Is it liver disease or what else?. Acta Paediatr. 2021; 111(3):459-461. DOI: 10.1111/apa.16213. View

Reddy N, Odish F, Agrawal S . Macro-Aspartate Aminotransferase: A Benign Cause of Abnormal Laboratory Findings. Cureus. 2022; 14(4):e23841. PMC: 9070560. DOI: 10.7759/cureus.23841. View

Lee M, Vajro P, Keeffe E . Isolated aspartate aminotransferase elevation: think macro-AST. Dig Dis Sci. 2011; 56(2):311-3. DOI: 10.1007/s10620-011-1575-4. View

Ono S, Kurata C, Nishimura N, Kawashima H, Yoneima R, Tai Y . Importance Of Laboratory Detection Of Macro-Aspartate Aminotransferase. Int J Gen Med. 2020; 12:433-436. PMC: 6884962. DOI: 10.2147/IJGM.S224281. View

Gonzalez Raya A, Coca Zuniga R, Martin Salido E . Isolated elevation of aspartate aminotransferase (AST) in an asymptomatic patient due to macro-AST. J Clin Lab Anal. 2018; 33(2):e22690. PMC: 6818607. DOI: 10.1002/jcla.22690. View

Li G . Aspartate aminotransferase: A prognostic marker rather than a specific liver injury marker in COVID-19. J Infect. 2020; 81(2):e155. PMC: 7276226. DOI: 10.1016/j.jinf.2020.06.007. View

Mrosewski I, Bredlau B, Ozturk Y, Switkowski R . Persistent Isolated Elevation of Aspartate Aminotransferase in an Asymptomatic Female Patient: a Case Report and Review of Current Literature. Clin Lab. 2019; 65(8). DOI: 10.7754/Clin.Lab.2019.190205. View

Rohani P, Imanzadeh F, Sayyari A, Kazemi Aghdam M, Shiari R . Persistent elevation of aspartate aminotransferase in a child after incomplete Kawasaki disease: a case report and literature review. BMC Pediatr. 2020; 20(1):73. PMC: 7025399. DOI: 10.1186/s12887-020-1975-8. View

Kulecka M, Wierzbicka A, Paziewska A, Mikula M, Habior A, Janczyk W . A heterozygous mutation in GOT1 is associated with familial macro-aspartate aminotransferase. J Hepatol. 2017; 67(5):1026-1030. DOI: 10.1016/j.jhep.2017.07.003. View

10.

Briani C, Zaninotto M, Forni M, Burra P . Macroenzymes: too often overlooked. J Hepatol. 2002; 38(1):119. DOI: 10.1016/s0168-8278(02)00333-1. View

11.

Davidson D, Watson D . Macroenzyme detection by polyethylene glycol precipitation. Ann Clin Biochem. 2003; 40(Pt 5):514-20. DOI: 10.1258/000456303322326425. View

12.

Burki C, Volleberg M, Blomgren L, Froese S, Hersberger M . Reference ranges for the polyethylene glycol (PEG) precipitation activity (%PPA) of eight routine enzyme activities. Pract Lab Med. 2022; 33:e00304. PMC: 9792387. DOI: 10.1016/j.plabm.2022.e00304. View

13.

Rubin A, Sass D, Stickle D . Distribution of serum concentrations reported for macroenzyme aspartate aminotransferase (macro-AST). Pract Lab Med. 2017; 8:65-69. PMC: 5575363. DOI: 10.1016/j.plabm.2017.05.003. View

14.

Sharma N, Darr U, Darr A, Sood G . Macro-aspartate Aminotransferase: Misleading Finding in a Patient with Non-alcoholic Fatty Liver Disease. Cureus. 2019; 11(6):e5042. PMC: 6716764. DOI: 10.7759/cureus.5042. View