Child Developmental MRI (CDM) Project: Protocol for a Multi-centre, Cross-sectional Study on Elucidating the Pathophysiology of Attention-deficit/hyperactivity Disorder and Autism Spectrum Disorder Through a Multi-dimensional Approach

Overview

Journal BMJ Open

Specialty General Medicine

Date 2023 Jun 24

PMID 37355265

Authors

Masatoshi Yamashita

Kuriko Kagitani-Shimono

Yoshiyuki Hirano

Sayo Hamatani

Shota Nishitani

Akiko Yao

Sawa Kurata

Hirotaka Kosaka

Minyoung Jung

Tokiko Yoshida

Tsuyoshi Sasaki

Koji Matsumoto

Yoko Kato

Mariko Nakanishi

Masaya Tachibana

Ikuko Mohri

Kenji J Tsuchiya

Tetsuya Tsujikawa

Hidehiko Okazawa

Eiji Shimizu

Masako Taniike

Akemi Tomoda

Yoshifumi Mizuno

Affiliations

Soon will be listed here.

Abstract

Introduction: Neuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have demonstrated differences in extensive brain structure, activity and network. However, there remains heterogeneity and inconsistency across these findings, presumably because of the diversity of the disorders themselves, small sample sizes, and site and parameter differences in MRI scanners, and their overall pathogenesis remains unclear. To address these gaps in the literature, we will apply the travelling-subject approach to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. In addition, we will investigate the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioural and psychological measures.

Methods And Analysis: We will collect resting-state functional MRI (fMRI) and T1-weighted and diffusion-weighted MRI data from 15 healthy adults as travelling subjects and 300 children (ADHD, n=100; ASD, n=100; and typical development, n=100) with multi-dimensional assessments. We will also apply data from more than 1000 samples acquired in our previous neuroimaging studies on ADHD and ASD.

Ethics And Dissemination: The study protocol has been approved by the Research Ethics Committee of the University of Fukui Hospital (approval no: 20220601). Our study findings will be submitted to scientific peer-reviewed journals and conferences.

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