(Gazaneh) Distillate Restores Glucose Metabolism in Diabetic Rats

Overview

Journal Int J Prev Med

Date 2023 Jun 23

PMID 37351057

Authors

Fahimeh Zamani-Garmsiri

Masoumeh Akmali

Ali Gohari

Fatemeh Zal

Atefeh Seghatoleslam

Affiliations

Soon will be listed here.

Abstract

Background: Diabetes has become an important health problem in the world. Natural agents, with antidiabetic property, are potential candidates for improving diabetes. Distillate () or Araghe Gazaneh is widely used for the treatment of diabetes as per traditional medicine. Despite the tremendous use of as an antidiabetic compound in folk medicine, the antidiabetic effects of has been neglected by medical scientists. In this study, we aimed to evaluate the effects of on the glucose metabolism in diabetic rats.

Methods: A total of 24 male rats were divided equally into four groups, two treatment and two control groups, each containing normal or Streptozotocin (STZ)-induced diabetic rats. During 4 weeks, control and treatment rats received water or , respectively. Fasting blood sugar (FBS), HbA1c, serum creatinine, blood urea nitrogen, and specific activities of hepatic enzymes including glucokinase (GK), hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), and muscle glucose transporter type 4 (GLUT4) and liver phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels were measured.

Results: FBS and HbA1c increased in diabetic groups. Treatment with significantly lowered FBS and prevented weight loss. Decreased FBS level was associated with higher activity levels of GK and HK in -treated diabetic rats. G6PD-specific activity decreased in diabetic control rats compared to nondiabetic ones, but treatment improved it to the normal levels. A significant decrease in the expression level of GLUT4 was observed in diabetic control rats compared to nondiabetic ones, but increased it to the normal levels.

Conclusions: These findings suggest that might exert therapeutic effects against diabetes by improving glucose metabolism and can be used as an alternative or complementary medicine for the treatment of diabetic patients.

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