Response to Comment on 'A Conserved Strategy for Inducing Appendage Regeneration in Moon Jellyfish, , and Mice'

Overview

Journal Elife

Specialty Biology

Date 2023 Jun 22

PMID 37347515

Authors

Yutian Li

Anish A Sarma

Iris T Lee

Fayth Hui Tan

Michael J Abrams

Zevin J Condiotte

Martin Heithe

Misha Raffiee

John O Dabiri

David A Gold

Lea Goentoro

Affiliations

Soon will be listed here.

Abstract

Previously we reported evidence that a regenerative response in the appendages of moon jellyfish, fruit flies, and mice can be promoted by nutrient modulation (Abrams et al., 2021). Sustar and Tuthill subsequently reported that they had not been able to reproduce the induced regenerative response in flies (Sustar and Tuthill, 2023). Here we discuss that differences in the amputation method, treatment concentrations, age of the animals, and stress management explain why they did not observe a regenerative response in flies. Typically, 30-50% of treated flies showed response in our assay.

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