» Articles » PMID: 37347299

Association Between Hip Bone Mineral Density and Mortality Risk After Hip Fracture: A Prospective Cohort Study

Overview
Specialty Pathology
Date 2023 Jun 22
PMID 37347299
Authors
Affiliations
Soon will be listed here.
Abstract

Factors related to mortality after osteoporotic hip fracture (HF) have been investigated intensively, except for proximal femoral bone mineral density (BMD), which is also the primary cause of osteoporosis. In this study, we aimed to investigate the association of hip BMD with mortality risk after HF. Four hundred and eleven elderly patients with HF in Beijing, China, were included and prospectively followed up with a median time of 3 years. At baseline, quantitative CT technique (QCT) was used to measure areal BMD (aBMD) of the unaffected hip. Areal BMDs of the total hip (TH), femoral neck (FN), trochanter (TR), and intertrochanter were analyzed with postoperative mortality as the primary outcome. A total of 394 patients (78.59 ± 7.59 years, 75.4% female) were included in our final analysis, with 86 (82.23 ± 7.00 years, 81.4% female) dead. All hip bone densities demonstrated a significant association with mortality risks in the unadjusted model, but only TR aBMD remained significantly correlated after adjusting for all covariates. Compared to the lower TR aBMD group, the higher TR aBMD group yielded significantly lower death risks (HR 0.21 95% CI 0.05-0.9, P = 0.036). Higher survival probabilities were observed for higher TH and TR aBMD in survival analysis (P < 0.001). Hip BMD, especially TR BMD assessed by QCT, is an independent risk factor for postoperative mortality following HF. QCT may present a promising avenue for opportunistic analysis in immobilized patients, providing valuable information for early detection and personalized interventions to enhance patient outcomes.

Citing Articles

Quantitative computed tomography analysis of proximal femur bone mineral density and its relation to hip fracture risk.

Xu Y, Zhu Y, Lin W, Lee D, Yang F, Fan Y Quant Imaging Med Surg. 2024; 14(12):9385-9393.

PMID: 39698675 PMC: 11651982. DOI: 10.21037/qims-24-1293.


Preoperative Thyroid-Stimulating Hormone Levels and Three-Year Mortality in Elderly Hip Fracture Patients: Insights from a Prospective Cohort Study.

Chen Y, Tu C, Liu G, Bei M, Zhang J, Tan Z Med Sci Monit. 2024; 30:e944465.

PMID: 39099160 PMC: 11312405. DOI: 10.12659/MSM.944465.

References
1.
Neuman M, Feng R, Carson J, Gaskins L, Dillane D, Sessler D . Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults. N Engl J Med. 2021; 385(22):2025-2035. DOI: 10.1056/NEJMoa2113514. View

2.
Cabrerizo S, Cuadras D, Gomez-Busto F, Artaza-Artabe I, Marin-Ciancas F, Malafarina V . Serum albumin and health in older people: Review and meta analysis. Maturitas. 2015; 81(1):17-27. DOI: 10.1016/j.maturitas.2015.02.009. View

3.
Boutin R, Bamrungchart S, Bateni C, Beavers D, Beavers K, Meehan J . CT of Patients With Hip Fracture: Muscle Size and Attenuation Help Predict Mortality. AJR Am J Roentgenol. 2017; 208(6):W208-W215. PMC: 5898447. DOI: 10.2214/AJR.16.17226. View

4.
Liu H, Shyu Y, Chou Y, Seak C, Lin Y, Tsai P . Combined Effects of Cognitive Impairment and Nutritional Trajectories on Functional Recovery for Older Patients after Hip-Fracture Surgery. J Am Med Dir Assoc. 2022; 23(12):1962.e15-1962.e20. DOI: 10.1016/j.jamda.2022.08.012. View

5.
Hsu Y, Li C, Liang F, Peng Z, Chang Y, Hsu J . Reduced All-Cause Mortality With Bisphosphonates Among Post-Fracture Osteoporosis Patients: A Nationwide Study and Systematic Review. Clin Pharmacol Ther. 2022; 112(3):711-719. DOI: 10.1002/cpt.2645. View